Large-scale topology and the default mode network in the mouse connectome

Stafford, James M.; Jarrett, Benjamin R.; Miranda-Domínguez, Óscar; Mills, Brian D.; Cain, Nicholas; Mihalaş, Ştefan; Lahvis, Garet P.; Lattal, K. Matthew; Mitchell, Suzanne H.; David, Stephen V.; Fryer, John Denis; Nigg, Joel T.; Fair, Damien A.

doi:10.1073/pnas.1404346111

Proc. Natl. Acad. Sci. U.S.A.

2014

DOI: 10.1073/pnas.1404346111

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Large-scale topology and the default mode network in the mouse connectome

James M. Stafford

¹

,

Benjamin R. Jarrett²,

Óscar Miranda-Domínguez³

et al.

Abstract: Noninvasive functional imaging holds great promise for serving as a translational bridge between human and animal models of various neurological and psychiatric disorders. However, despite a depth of knowledge of the cellular and molecular underpinnings of atypical processes in mouse models, little is known about the large-scale functional architecture measured by functional brain imaging, limiting translation to human conditions. Here, we provide a robust processing pipeline to generate high-resolution, whole… Show more

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Cited by 256 publications

(343 citation statements)

References 65 publications

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“…4A), three functional modules were observed: the first two encompassed the sensorimotor region (1: orofacial regions; 2: limb regions), whereas the third one was associated with medial posterior areas (3: visual cortex and RS). In agreement with previous studies (Mohajerani et al, 2010;Sforazzini et al, 2014), strong interhemispheric correspondence was observed (correlation of patterns between both hemispheres: r ϭ 0.44 Ϯ 0.05, 0.59 Ϯ 0.04 and 0.46 Ϯ 0.04 for gradient, SD, and Louvain boundaries maps, respectively; for all, p Ͻ 0.001, one-sample t test for the hypothesis that the data are centered to 0) as well as consistent patterns between Louvain boundaries and gradient or SD maps (Fig. 5E).…”

Section: Resultssupporting

confidence: 94%

Mesoscale Mapping of Mouse Cortex Reveals Frequency-Dependent Cycling between Distinct Macroscale Functional Modules

Vanni

¹

,

Chan

²

,

Balbi

³

et al. 2017

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…4A), three functional modules were observed: the first two encompassed the sensorimotor region (1: orofacial regions; 2: limb regions), whereas the third one was associated with medial posterior areas (3: visual cortex and RS). In agreement with previous studies (Mohajerani et al, 2010;Sforazzini et al, 2014), strong interhemispheric correspondence was observed (correlation of patterns between both hemispheres: r ϭ 0.44 Ϯ 0.05, 0.59 Ϯ 0.04 and 0.46 Ϯ 0.04 for gradient, SD, and Louvain boundaries maps, respectively; for all, p Ͻ 0.001, one-sample t test for the hypothesis that the data are centered to 0) as well as consistent patterns between Louvain boundaries and gradient or SD maps (Fig. 5E).…”

Section: Resultssupporting

confidence: 94%

Mesoscale Mapping of Mouse Cortex Reveals Frequency-Dependent Cycling between Distinct Macroscale Functional Modules

Vanni

¹

,

Chan

²

,

Balbi

³

et al. 2017

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Our findings are in close agreement with a recent study reporting that anatomical connectivity predicts fcMRI results in anesthetized mice based on whole-brain connectivity matrices (Stafford et al 2014). Here, we were able to replicate this finding in awake mice and extend the analysis by comparing structure–function relations between different cortical systems.…”

Section: Resultssupporting

confidence: 93%

The Organization of Mouse and Human Cortico-Hippocampal Networks Estimated by Intrinsic Functional Connectivity

Bergmann

¹

,

Zur

²

,

Bershadsky

³

et al. 2016

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…independent component analysis, Fig. S5) previously used by other groups, and well agreed with the rodent DMN pattern reported in the literature (Hsu et al, 2016; Lu et al, 2012; Stafford et al, 2014). Notably, we found that the BF was a prominent node in the rodent DMN, which was not observed in other rodent DMN mapping studies, but was reported in an electrophysiology study that demonstrated that the BF is a key DMN node and critical in regulating DMN-related behaviors in rats (Nair et al, 2018).…”

Section: Resultssupporting

confidence: 89%

How brain reacts to targeted attack at a hub region

Tu,

Ma,

Ma

et al. 2019

Preprint

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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