The Organization of Mouse and Human Cortico-Hippocampal Networks Estimated by Intrinsic Functional Connectivity

Bergmann, Eyal; Zur, Gil; Bershadsky, Guy; Kahn, Itamar

doi:10.1093/cercor/bhw327

Cereb. Cortex

2016

DOI: 10.1093/cercor/bhw327

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

The Organization of Mouse and Human Cortico-Hippocampal Networks Estimated by Intrinsic Functional Connectivity

Eyal Bergmann

¹

,

Gil Zur

²

,

Guy Bershadsky

³

et al.

Abstract: While the hippocampal memory system has been relatively conserved across mammals, the cerebral cortex has undergone massive expansion. A central question in brain evolution is how cortical development affected the nature of cortical inputs to the hippocampus. To address this question, we compared cortico-hippocampal connectivity using intrinsic functional connectivity MRI (fcMRI) in awake mice and humans. We found that fcMRI recapitulates anatomical connectivity, demonstrating sensory mapping within the mouse … Show more

Help me understand this report

Cited by 109 publications

(132 citation statements)

References 83 publications

Supporting

3

Mentioning

129

Contrasting

0

Unclassified

0

Order By: Relevance

“…The aCC contains axons related to the somatomotor system connecting the two hemispheres, and the integrity of this system is reflected in rotarod performance ( 41 ). As expected, the control group showed homotopicity (symmetric bilateral correlations), a hallmark of rs-fMRI in humans and rodents ( 29 , 32 , 34 , 35 , 42 ). In contrast, Plp- Nf1 fl/+ mice showed reduced interhemispheric connectivity ( Fig.…”

Section: Resultssupporting

confidence: 78%

Brain-wide structural and functional disruption in mice with oligodendrocyte-specific Nf1 deletion is rescued by inhibition of nitric oxide synthase

Asleh

¹

,

Shofty

²

,

Cohen

³

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…The aCC contains axons related to the somatomotor system connecting the two hemispheres, and the integrity of this system is reflected in rotarod performance ( 41 ). As expected, the control group showed homotopicity (symmetric bilateral correlations), a hallmark of rs-fMRI in humans and rodents ( 29 , 32 , 34 , 35 , 42 ). In contrast, Plp- Nf1 fl/+ mice showed reduced interhemispheric connectivity ( Fig.…”

Section: Resultssupporting

confidence: 78%

Brain-wide structural and functional disruption in mice with oligodendrocyte-specific Nf1 deletion is rescued by inhibition of nitric oxide synthase

Asleh

¹

,

Shofty

²

,

Cohen

³

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Since such algorithms have yet to be adapted to mice, and are beyond the scope of the current work, we used anatomical parcellation based on the Allen Mouse Brain Atlas, which is comprised of 86 cortical labels 33,34 . Previous studies in mice showed close agreement between structural and functional connectivity in the mouse brain 27,54 , including in gross cortical organization 55 . Moreover, using the Allen Mouse Brain Atlas, we have recently shown that structural connectomes can predict their functional counterpart 30 , suggesting that this anatomical parcellation is functionally relevant.…”

Section: Discussionsupporting

confidence: 56%

Individual variability in functional connectivity architecture of the mouse brain

Bergmann

¹

,

Gofman

²

,

Kavushansky

³

et al. 2020

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…This could be due to the difference in how reproducibility was measured in the task and resting fMRI (see more discussion in the reproducibility subsection below). Furthermore, the use of GSR led to reduced or even negative FC similar to what has been reported in rodents (Bergmann et al, 2016;Kalthoff et al, 2013) and humans (Murphy et al, 2009). Therefore, the results discourage the use of GSR in rodent rsfMRI preprocessing.…”

Section: Accepted Manuscriptsupporting

confidence: 51%

Evaluation of nuisance removal for functional MRI of rodent brain

Chuang

¹

,

Lee

²

,

Li

³

et al. 2019

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA