How brain reacts to targeted attack at a hub region

Tu, Wenyu; Ma, Zilu; Ma, Yuncong; Zhang, Nanyin

doi:10.1101/767863

2019

DOI: 10.1101/767863

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How brain reacts to targeted attack at a hub region

Wenyu Tu,

Zilu Ma,

Yuncong Ma

et al.

Abstract: 22The architecture of brain networks has been extensively studied in multiple species. 23 However, exactly how the brain network reconfigures when a local region stops 24 functioning remains elusive. By combining chemogenetics and resting-state functional 25 magnetic resonance imaging (rsfMRI) in awake rodents, we investigated the causal 26 impact of acutely inactivating a hub region (i.e. dorsal anterior cingulate cortex) on brain 27 network properties. We found that disrupting hub activity profoundly chan… Show more

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“…Animal models provide unique possibilities to perform longitudinal, multiparametric and experimental assessment of whole-brain structural and functional reorganization after stroke or TBI (Dijkhuizen and Nicolay, 2003;Fluri et al, 2015;Xiong et al, 2013). In addition, these studies may be strengthened by the application of recently developed neurostimulatory techniques such as transcranial magnetic stimulation (TMS) (Lindenberg et al, 2010;Stinear et al, 2007;Villamar et al, 2012) and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) (Roelofs et al, 2017;Tu and Zhang, 2019) in rodents. Both DREADDs and TMS have already been successfully applied in our lab (Boonzaier et al, 2018;Roelofs et al, 2017).…”

Section: The Brain As a Complex And Integrative Networkmentioning

confidence: 99%

MRI-based Measurement of Structural and Functional Connectivity in Health and Disease

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Animal models provide unique possibilities to perform longitudinal, multiparametric and experimental assessment of whole-brain structural and functional reorganization after stroke or TBI (Dijkhuizen and Nicolay, 2003;Fluri et al, 2015;Xiong et al, 2013). In addition, these studies may be strengthened by the application of recently developed neurostimulatory techniques such as transcranial magnetic stimulation (TMS) (Lindenberg et al, 2010;Stinear et al, 2007;Villamar et al, 2012) and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) (Roelofs et al, 2017;Tu and Zhang, 2019) in rodents. Both DREADDs and TMS have already been successfully applied in our lab (Boonzaier et al, 2018;Roelofs et al, 2017).…”

Section: The Brain As a Complex And Integrative Networkmentioning

confidence: 99%

MRI-based Measurement of Structural and Functional Connectivity in Health and Disease

Sinke¹

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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