Mesoscale Mapping of Mouse Cortex Reveals Frequency-Dependent Cycling between Distinct Macroscale Functional Modules

Vanni, Matthieu P.; Chan, Allen W.; Balbi, Matilde; Silasi, Gergely; Murphy, Timothy H.

doi:10.1523/jneurosci.3560-16.2017

J. Neurosci.

2017

DOI: 10.1523/jneurosci.3560-16.2017

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Mesoscale Mapping of Mouse Cortex Reveals Frequency-Dependent Cycling between Distinct Macroscale Functional Modules

Matthieu P. Vanni

¹

,

Allen W. Chan

²

,

Matilde Balbi

³

et al.

Abstract: Connectivity mapping based on resting-state activity in mice has revealed functional motifs of correlated activity. However, the rules by which motifs organize into larger functional modules that lead to hemisphere wide spatial-temporal activity sequences is not clear. We explore cortical activity parcellation in head-fixed, quiet awake GCaMP6 mice from both sexes by using mesoscopic calcium imaging. Spectral decomposition of spontaneous cortical activity revealed the presence of two dominant frequency modes (… Show more

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Cited by 164 publications

(234 citation statements)

References 107 publications

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“…However, temporal down sampling below 10Hz resulted in a shift of the signal and noise peaks (Δp1 = 0.06), and a reduction in the peak-to-peak distance (Δp−p = 0.02). This result agrees with previous analyses that found 10Hz to be the minimal sampling frequency required for measuring population calcium dynamics [ 15 ].…”

Section: Resultssupporting

confidence: 93%

Data-driven segmentation of cortical calcium dynamics

Weiser

¹

,

Mullen

²

,

Ascencio

³

et al. 2023

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…However, temporal down sampling below 10Hz resulted in a shift of the signal and noise peaks (Δp1 = 0.06), and a reduction in the peak-to-peak distance (Δp−p = 0.02). This result agrees with previous analyses that found 10Hz to be the minimal sampling frequency required for measuring population calcium dynamics [ 15 ].…”

Section: Resultssupporting

confidence: 93%

Data-driven segmentation of cortical calcium dynamics

Weiser

¹

,

Mullen

²

,

Ascencio

³

et al. 2023

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Within MOp, we found a separation between anterior and posterior subdivisions, in line with previous literature 17 – 19 reporting a difference between the ALM area and the M1 proper (this subdivision has also been reported as the rostral forelimb area [RFA] and the caudal forelimb area [CFA] 20 – 22 ) within the MOp. As such, we will refer to these areas as ALM and M1.…”

Section: Resultssupporting

confidence: 91%

The mouse motor system contains multiple premotor areas and partially follows human organizational principles

Lazari

¹

,

Tachrount

²

,

Valverde

³

et al. 2024

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…To facilitate comparison with standard disjoint algorithms, we also determined a version of the network assignment in which brain regions were assigned the network label with the largest membership value. Our results are also in agreement with those based on Ca 2+ seed-based correlation maps [31, 32, 37, 38, 54, 56], especially for BOLD and . With 7 communities, well-defined visual and lateral cortical networks (OC2 and OC3, respectively) were again identified [14,16,18], together with additional systems covering bilateral and well-defined cortical territories (Figure 2C).…”

Section: Resultssupporting

confidence: 90%

Multimodal measures of spontaneous brain activity reveals both common and divergent patterns of cortical functional organization

Vafaii

¹

,

Mandino

²

,

Desrosiers-Grégoire

³

et al. 2022

Preprint

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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