Neuron
 2016
DOI: 10.1016/j.neuron.2016.09.004
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

Balancing the Robustness and Efficiency of Odor Representations during Learning

Monica W. Chu
1
,
Wankun L. Li
2
,
Takaki Komiyama
3

Abstract: Summary For reliable stimulus identification, sensory codes have to be robust by including redundancy to combat noise, but redundancy sacrifices coding efficiency. To address how experience affects the balance between the robustness and efficiency of sensory codes, we probed odor representations in the mouse olfactory bulb during learning over a week, using longitudinal two-photon calcium imaging. When mice learned to discriminate between two dissimilar odorants, responses of mitral cell ensembles to the two o… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
88
37
26
11

Citation Types

27
158
2
0

Year Published

2016
2016
2026
2026

Publication Types

Select...
83
42
5
3

Relationship

5
128

Authors

Journals

citations

Cited by 131 publications

(187 citation statements)
references

References 63 publications

27
158
2
0
Order By: Relevance
“…We note that the decoder performance was relatively stable throughout imaging, in contrast to our recent report in which the decoder performance improved during difficult discrimination learning and correlated with behavioral choice on a trial-by-trial basis ( Chu et al, 2016 ). The apparent discrepancy likely stems from the fact that Chu et al investigated changes of representations of novel odorants over time, while in the current study, mice had already been familiarized with the odorants, albeit at different mixture ratios, during the easy discrimination task prior to imaging.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…We note that the decoder performance was relatively stable throughout imaging, in contrast to our recent report in which the decoder performance improved during difficult discrimination learning and correlated with behavioral choice on a trial-by-trial basis ( Chu et al, 2016 ). The apparent discrepancy likely stems from the fact that Chu et al investigated changes of representations of novel odorants over time, while in the current study, mice had already been familiarized with the odorants, albeit at different mixture ratios, during the easy discrimination task prior to imaging.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The number of divergent cells, however, actually increased by a small amount ( Fig 2H ). Thus, both results recapitulated the experimental observations [ 26 ]. These outcomes were not sensitive to the threshold θ that classified the cells ( S14 Fig ).…”
Section: Resultssupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Concomitantly, discriminability of stimulus representations is altered through selective boosting of responses of discriminating neurons (Figure 2h). These divergent responses occurred in about 12% of the neurons we observed, closely matching a previous report (Chu et al, 2016).…”
Section: Discussionsupporting
confidence: 93%
“…Modelling studies suggest that these are most often neurons with a preferred stimulus feature that is shifted slightly away from the stimulus features to be discriminated (Jazayeri and Movshon, 2006). These, in our case, comprise about 12% of the imaged neurons, which closely match previous reports (Chu et al, 2016). Our results suggest that such neurons may be the target of selective and dynamic modulation to enable enhanced discriminability as needed.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo