Elife
 2018
DOI: 10.7554/elife.33006
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Adult-born neurons facilitate olfactory bulb pattern separation during task engagement

Wankun L. Li
1
,
Monica W. Chu
2
,
An Wu
3
et al.

Abstract: The rodent olfactory bulb incorporates thousands of newly generated inhibitory neurons daily throughout adulthood, but the role of adult neurogenesis in olfactory processing is not fully understood. Here we adopted a genetic method to inducibly suppress adult neurogenesis and investigated its effect on behavior and bulbar activity. Mice without young adult-born neurons (ABNs) showed normal ability in discriminating very different odorants but were impaired in fine discrimination. Furthermore, two-photon calciu… Show more

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Cited by 89 publications

(75 citation statements)
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“…Mice improved their performance in this difficult discrimination task over 9 days ( Fig. 1I), consistent with our previous report (27). The behavioral improvement here which reached ~65% correct rate was worse than what we reported in our previous study (~76%) (27).…”
Section: Results Abgcs Show Task-induced Functional Plasticitysupporting
confidence: 92%
“…1I), consistent with our previous report (27). The behavioral improvement here which reached ~65% correct rate was worse than what we reported in our previous study (~76%) (27). This is likely due to a small change in the training procedure that we made.…”
Section: Results Abgcs Show Task-induced Functional Plasticitysupporting
confidence: 91%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Mice improved their performance in this difficult discrimination task over 9 days ( Fig. 1I), consistent with our previous report (27). The behavioral improvement here which reached ~65% correct rate was worse than what we reported in our previous study (~76%) (27).…”
Section: Results Abgcs Show Task-induced Functional Plasticitysupporting
confidence: 92%
“…1I), consistent with our previous report (27). The behavioral improvement here which reached ~65% correct rate was worse than what we reported in our previous study (~76%) (27). This is likely due to a small change in the training procedure that we made.…”
Section: Results Abgcs Show Task-induced Functional Plasticitysupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…As we observed empirically, abGCs increase the dynamic range of MCs, thereby improving discrimination. Notably, this is consistent with the effects observed in numerous causal behavioral experiments 14,15,45 . Better discriminatory power by MCs can serve downstream areas, improving multiple computations such as pattern separation 14,65 .…”
Section: Discussionsupporting
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…1c), and are more strongly driven by OSN input 30 . Given these findings and, consistent with previous work 52,[88][89][90][91] , we speculate that the mitral cell-to-PC loop is not primarily involved in the sensory aspects of odor identification, which appear readily supported by the non-canonical TC-to-AON pathway, and rather performs different computations. For example, it may specifically modify odor representations during contextual learning, and/or relay sensory and sensorimotor predictions in complex, fluctuating olfactory scenes.…”
Section: Discussionsupporting
confidence: 88%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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