Elife
 2019
DOI: 10.7554/elife.43558
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

Rapid task-dependent tuning of the mouse olfactory bulb

Anzhelika Koldaeva
1
,
Andreas T. Schaefer
2
,
Izumi Fukunaga
3

Abstract: Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on the stimulus tuning of a given neuron, making olfactory responses more discriminable through selective amplification in a demand-specific way.

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
37
7
5
4

Citation Types

4
33
0
0

Year Published

2019
2019
2025
2025

Publication Types

Select...
29
15
2
2

Relationship

8
40

Authors

Journals

citations

Cited by 48 publications

(37 citation statements)
references

References 34 publications

4
33
0
0
Order By: Relevance
“…These data show that task information is strongly represented in MC responses beyond the information about the chemicals themselves. These data are consistent with numerous reports that show task information in neuronal responses [17,18,20,22,23].…”
Section: Mcs Carry Information About the Task And The Animal's Choicesupporting
confidence: 93%
“…Interestingly, when animals learned to discriminate between two very similar odour mixtures, the representation of odours by MCs diverged, improving discriminability [17,18]. However, when the task demand was different and animals were forced to group the same odour mixtures together, the representations of the exact same odours converged again [23]. Our data extends these observations, showing that neural signatures in the OB correlate with even more abstract representations that encode the behavioural relevance of stimuli.…”
Section: Flexible Categorisation Following Learningsupporting
confidence: 69%
“…Dynamic changes in the OB following learning were reported by other studies as well [17,18,23,70]. Interestingly, when animals learned to discriminate between two very similar odour mixtures, the representation of odours by MCs diverged, improving discriminability [17,18].…”
Section: Flexible Categorisation Following Learningsupporting
confidence: 61%
See 2 more Smart Citations
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…These data show that task information is strongly represented in MC responses beyond the information about the chemicals themselves. These data are consistent with numerous reports that show task information in neuronal responses [17,18,20,22,23].…”
Section: Mcs Carry Information About the Task And The Animal's Choicesupporting
confidence: 93%
“…Interestingly, when animals learned to discriminate between two very similar odour mixtures, the representation of odours by MCs diverged, improving discriminability [17,18]. However, when the task demand was different and animals were forced to group the same odour mixtures together, the representations of the exact same odours converged again [23]. Our data extends these observations, showing that neural signatures in the OB correlate with even more abstract representations that encode the behavioural relevance of stimuli.…”
Section: Flexible Categorisation Following Learningsupporting
confidence: 69%
“…Dynamic changes in the OB following learning were reported by other studies as well [17,18,23,70]. Interestingly, when animals learned to discriminate between two very similar odour mixtures, the representation of odours by MCs diverged, improving discriminability [17,18].…”
Section: Flexible Categorisation Following Learningsupporting
confidence: 61%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…reports of some association-related modification of odor representations as early as the olfactory bulb (Chu et al, 2016;Doucette et al, 2011;Koldaeva et al, 2019;Li et al, 2015). Considering we detected value and especially value-like coding in AON, DP, and TTd, perhaps these regions are a crucial first step in processing and amplifying task-related input from the olfactory bulb.…”
Section: Widespread Value Signalingsupporting
confidence: 48%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Given the presence of value coding in olfactory cortex, the question remains of where odor information is first transformed into a value signal. In fact, there have been multiple reports of some association-related modification of odor representations as early as the olfactory bulb (Chu et al, 2016;Doucette et al, 2011;Koldaeva et al, 2019;Li et al, 2015). Considering the prevalence of value and non-value trial type coding we observed in AON, DP, and TTd, perhaps these regions are a crucial first step in processing and amplifying task-related input from the olfactory bulb.…”
Section: Widespread Value Signalingmentioning
confidence: 57%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo