Eur J Immunol
 2009
DOI: 10.1002/eji.200838693
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Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease

Jayne S. Sutherland
1
,
Ifedayo Adetifa
2
,
Philip C. Hill
3
et al.

Abstract: Tuberculosis (TB) remains a global health problem. The solution involves development of an effective vaccine, but has been limited by incomplete understanding of what constitutes protective immunity during natural infection with Mycobacterium tuberculosis. In this study, M. tuberculosis-specific responses following an overnight whole-blood assay were assessed by intracellular cytokine staining and luminex, and compared between TB cases and exposed household contacts. TB cases had significantly higher levels of… Show more

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Cited by 201 publications

(194 citation statements)
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“…These results differ from those in the study by Sutherland et al [20], where no IL-17 responses were detected at all. Th-17 cells have been suggested to play a role in human TB immunity through the recruitment of neutrophils in granuloma-formation, thus functioning as a bridge between innate and adaptive immunity [33].…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…These results differ from those in the study by Sutherland et al [20], where no IL-17 responses were detected at all. Th-17 cells have been suggested to play a role in human TB immunity through the recruitment of neutrophils in granuloma-formation, thus functioning as a bridge between innate and adaptive immunity [33].…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…In contrast to our results that show that the broad and multifunctional cytokine pattern induced by HBHA is indicative of protection/nondisease progression, others have shown increased cytokine production by multiplex cytokine arrays in active TB disease (36). However, the techniques employed in this study and those in the Sutherland paper measure different parameters and are not directly comparable.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…With regard to ESAT-6-reactive CD4+ T-cells, we observed similar trends for relative and absolute frequencies as seen for PPD, but as some samples did not respond to ESAT-6 and, consistent with previous studies [29], [30], [33], the responses were generally weaker and significance was not obtained for these changes (data not shown).…”
Section: Resultssupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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