PLoS ONE
 2012
DOI: 10.1371/journal.pone.0043438
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Immune Responses to ESAT-6 and CFP-10 by FASCIA and Multiplex Technology for Diagnosis of M. tuberculosis Infection; IP-10 Is a Promising Marker

Emilie Wahren Borgström
1
,
Peter Andersen
2
,
Fredrik Atterfelt
3
et al.

Abstract: BackgroundThere is a need for reliable markers to diagnose active and latent tuberculosis (TB). The interferon gamma release assays (IGRAs) are compared to the tuberculin skin test (TST) more specific, but cannot discriminate between recent or remote TB infection. Here the Flow-cytometric Assay for Specific Cell-mediated Immune-response in Activated whole blood (FASCIA), which quantifies expanded T-lymphoblasts by flow-cytometric analysis after long-term antigen stimulation of whole blood, is combined with cyt… Show more

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Cited by 50 publications

(31 citation statements)
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“…In agreement with previous studies, we observed elevated IP-10 levels in LTBI individuals after stimulation with ESAT-6 and CFP-10 compared to healthy individuals ( Borgström et al, 2012 ; Jeong et al, 2015 ; Comella-Del-Barrio et al, 2019 ). Biraro et al (2016) previously showed that IP-10 performed well in differentiating contacts with either latent or active TB from those who were uninfected in Uganda.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…In agreement with previous studies, we observed elevated IP-10 levels in LTBI individuals after stimulation with ESAT-6 and CFP-10 compared to healthy individuals ( Borgström et al, 2012 ; Jeong et al, 2015 ; Comella-Del-Barrio et al, 2019 ). Biraro et al (2016) previously showed that IP-10 performed well in differentiating contacts with either latent or active TB from those who were uninfected in Uganda.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…7 In addition, the analysis of Kruskal-Wallis test showed that there was no significant difference in changes in the percentage of CD3 + T-lymphocytes expressing IFN-γ before and after CFP-10 stimulation between groups (P=0.143) as shown in Table 3. The results of this research were different from the results of a study conducted by Borgström et al 8 stating that there was a significant increased production of IFN-γ in patients with active TB compared to healthy people after stimulation of specific antigens of Mycobacterium tuberculosis, ESAT-6 and CFP-10 (P<0.05). The significant increased production of IFN-γ in patients with active TB after the stimulation was also correlated with the proliferative response of T lymphocytes.…”
contrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…When comparing responses seen to ESAT-6/CFP10 compared to responses to ESAT-6 alone, we have rarely seen more than a 3% difference in the magnitude of the response and have not observed significant differences in the type of response evoked. This observation has been confirmed by other groups showing the detailed comparison where the responses are strikingly similar [27] - [29] .…”
Section: Discussionsupporting
confidence: 85%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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