Clin. Vaccine Immunol.
 2012
DOI: 10.1128/cvi.00047-12
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Heparin-Binding Hemagglutinin Induces IFN-γ+IL-2+IL-17+Multifunctional CD4+T Cells during Latent but Not Active Tuberculosis Disease

André G. Loxton
1
,
Gillian F. Black
2
,
Kim Stanley
3
et al.
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Cited by 25 publications

(18 citation statements)
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“…In the present study, we detected a small but significant number of IL-17A-producing CD4 ＋ T cells in response to HBHA in TB cases. This is compatible with a previous finding that HBHA-specific memory CD4 ＋ T cells are present in vivo (33). To clarify the role of this IL-17 immune response in the course of M. tuberculosis infection, it is worth investigating the IL-17 response to HBHA in a cohort of early M. tuberculosis exposure population.…”
Section: Discussionsupporting
confidence: 63%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…In the present study, we detected a small but significant number of IL-17A-producing CD4 ＋ T cells in response to HBHA in TB cases. This is compatible with a previous finding that HBHA-specific memory CD4 ＋ T cells are present in vivo (33). To clarify the role of this IL-17 immune response in the course of M. tuberculosis infection, it is worth investigating the IL-17 response to HBHA in a cohort of early M. tuberculosis exposure population.…”
Section: Discussionsupporting
confidence: 63%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…As has been reported in mice, IL‐17 + γ‐δ T cells have also been found to be increased in human TB patients . Notably, the M. tuberculosis antigen HBHA can also activate Th17 cells; HBHA stimulation ex vivo induced activation of a greater frequency of CD4 + T cells co‐expressing IFN‐γ, IL‐2, and IL‐17 in household contacts as compared to active TB patients . In summary, Th17 and other IL‐17‐producing cells appear to contribute to M. tuberculosis control, most likely at an early stage of infection, and differences in pathogenic M. tuberculosis strains may play a role in differential Th17 responses observed in humans.…”
Section: T‐cell Activation After M Tuberculosis Infectionsupporting
confidence: 64%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Important for this antigen is the role of measuring cytokines other than IFN-γ, as two other studies measuring IFN-γ only did not find significant differences in patients with TB disease, TB infection and controls (28,31). A further study including a subgroup of four HIV-infected individuals also did not find noteworthy responses of IFN-γ induced by Rv2031c and two cytokines that were not measured in our study (IL-2, IL-17) (32).…”
Section: Discussioncontrasting
confidence: 49%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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