The Lancet Infectious Diseases
 2012
DOI: 10.1016/s1473-3099(11)70295-x
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Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

Michael T. Osterholm
1
,
Nicholas S. Kelley
2
,
Alfred Sommer
3
et al.
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Cited by 1,751 publications

(1,311 citation statements)
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“…Using a ≥2-fold increase from baseline post-LAIV as a significant response 6 , none of ten subjects showed a H1N1pdm09-specific response, with one subject showing a H3N2-specific response in ELISAmeasured influenza-specific IgA data. This is consistent with previous reports of lower LAIV efficacy in adults compared to children 17 and poor antibody responses to H1N1pdm09 compared to H3N2 or influenza B components in LAIV even in children 18,19 . Interestingly, when we considered the influenza-specific IgA data generated by HA microarray, three subjects showed a significant response to H1 HA and three subjects to H3 HA (2 subjects showed a ≥2-fold increase to both H1pdm09 and H3 HA).…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Using a ≥2-fold increase from baseline post-LAIV as a significant response 6 , none of ten subjects showed a H1N1pdm09-specific response, with one subject showing a H3N2-specific response in ELISAmeasured influenza-specific IgA data. This is consistent with previous reports of lower LAIV efficacy in adults compared to children 17 and poor antibody responses to H1N1pdm09 compared to H3N2 or influenza B components in LAIV even in children 18,19 . Interestingly, when we considered the influenza-specific IgA data generated by HA microarray, three subjects showed a significant response to H1 HA and three subjects to H3 HA (2 subjects showed a ≥2-fold increase to both H1pdm09 and H3 HA).…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…In fact, TIV tended to have a low effectiveness in preventing influenza among 2–6 year-old children and a moderate VE among 7–17 year-old children. Our results are in line with other studies determining a higher effectiveness of LAIV compared to TIV in children up to 6–7 years of age [ 2 , 5 – 8 ]. For example, LAIV had a higher effect than TIV in preventing influenza caused by antigenically-matching viral strains in a phase III trial in children aged 6–59 months.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Our results are in concordance with findings of published meta-analyses of randomized trials of influenza vaccines [11,12]. They are also consistent with the conclusions of previous pandemic influenza VE studies conducted in other European countries [9,13-16] and Canada [17], where it was concluded that, overall, the pandemic influenza vaccine was highly effective in preventing laboratory-confirmed infection with pandemic influenza A(H1N1)pdm09.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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