IUCrJ
 2021
DOI: 10.1107/s2052252521009076
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virusMED: an atlas of hotspots of viral proteins

Huihui Zhang
1
,
Pei Chen
2
,
Haojie Ma
3
et al.

Abstract: Metal binding sites, antigen epitopes and drug binding sites are the hotspots in viral proteins that control how viruses interact with their hosts. virusMED (virus Metal binding sites, Epitopes and Drug binding sites) is a rich internet application based on a database of atomic interactions around hotspots in 7041 experimentally determined viral protein structures. 25306 hotspots from 805 virus strains from 75 virus families were characterized, including influenza, HIV-1 and SARS-CoV-2 virus… Show more

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“…The polypeptide chain that forms the most coordinating bonds with the subject metal ion is characterized and used as the CK/CKR source of the metal binding site. The quality of each metal binding site is evaluated using the previously described algorithm used in the validation of magnesium binding sites in nucleic acid structures [46], with modification in the validation of metal binding sites in viral structures [47].…”
Section: Small Molecule and Metal Targeting Surfacesmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The polypeptide chain that forms the most coordinating bonds with the subject metal ion is characterized and used as the CK/CKR source of the metal binding site. The quality of each metal binding site is evaluated using the previously described algorithm used in the validation of magnesium binding sites in nucleic acid structures [46], with modification in the validation of metal binding sites in viral structures [47].…”
Section: Small Molecule and Metal Targeting Surfacesmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…VirusMED (https://virusmed.biocloud.top/ (accessed on 5 July 2022)) is a database of epitopes, drug-binding site and metal-binding sites in viral proteins of known 3D structures [71]. For metal-binding sites, this database provides information on the coordination bonds between the protein and the metal ion(s).…”
Section: Metalloprotein Databasesmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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