CytoSIP: An annotated structural atlas for interactions involving cytokine or cytokine receptor

Abstract: Therapeutic agents targeting cytokine-cytokine receptor (CK-CKR) interactions lead to the disruption in cellular signaling and are effective in treating many diseases including tumors. However, a lack of universal and quick access to annotated structural surface regions on CK/CKR has limited the progress of a structure-driven approach in developing targeted macromolecular drugs and precision medicine therapeutics. Herein we report CytoSIP (Single nucleotide polymorphisms (SNPs), Interface, and Phenotype), a da… Show more