The Coviral Portal: Multi-Cohort Viral Loads and Antigen-Test Virtual Trials for COVID-19

Morgan, Alexandra; Contreras, Elisa; Yasuda, Michie; Dutta, Sanjucta; Hamel, Donald J.; Shankar, Tarini; Balallo, Diane; Riedel, Stefan; Kirby, James E.; Kanki, Phyllis; Arnaout, Ramy

doi:10.1101/2023.05.05.23289582

2023

DOI: 10.1101/2023.05.05.23289582

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The Coviral Portal: Multi-Cohort Viral Loads and Antigen-Test Virtual Trials for COVID-19

Alexandra Morgan

¹

,

Elisa Contreras

²

,

Michie Yasuda

³

et al.

Abstract: Background. Regulatory approval of new over-the-counter tests for infectious agents such as SARS-CoV-2 has historically required that clinical trials include diverse groups of specific patient populations, making the approval process slow and expensive. Showing that populations do not differ in their viral loads---the key factor determining test performance---could expedite the evaluation of new tests. Methods. 46,726 RT-qPCR-positive SARS-CoV-2 viral loads were annotated with patient demographics and health s… Show more

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Cited by 1 publication

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“…And sixth, accessing clinical annotations from electronic medical records can be challenging. 33 As a result, the effect of clinical heterogeneity in AIRRseq studies in the setting of COVID-19 has been under-explored to date.…”

Section: Introductionmentioning

confidence: 99%

“…And sixth, accessing clinical annotations from electronic medical records can be challenging. 33 As a result, the effect of clinical heterogeneity in AIRRseq studies in the setting of COVID-19 has been under-explored to date. In all, the work above supports the view that there are commonalities in IGH and TRB at the gene and sequence level in response to SARS-CoV-2 infection; however, the nature of the signature is not well understood.…”

Section: Introductionmentioning

confidence: 99%

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Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires

Braun

¹

,

Hill

²

,

Contreras

³

et al. 2023

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…And sixth, accessing clinical annotations from electronic medical records can be challenging. 33 As a result, the effect of clinical heterogeneity in AIRRseq studies in the setting of COVID-19 has been under-explored to date.…”

Section: Introductionmentioning

confidence: 99%

“…And sixth, accessing clinical annotations from electronic medical records can be challenging. 33 As a result, the effect of clinical heterogeneity in AIRRseq studies in the setting of COVID-19 has been under-explored to date. In all, the work above supports the view that there are commonalities in IGH and TRB at the gene and sequence level in response to SARS-CoV-2 infection; however, the nature of the signature is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires

Braun

¹

,

Hill

²

,

Contreras

³

et al. 2023

Preprint

Self Cite

1

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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