2023 Preprint
Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires
Abstract: Antibodies and helper T cells play important roles in SARS-CoV-2 infection and vaccination. We sequenced B– and T-cell receptor repertoires (BCR/TCR) from the blood of 251 infectees, vaccinees, and controls to investigate whether features of these repertoires could predict subjects’ SARS-CoV-2 neutralizing antibody titer (NAbs), as measured by enzyme-linked immunosorbent assay (ELISA). We sequenced recombined immunoglobulin heavy-chain (IGH), TCRβ (TRB), and TCRδ (TRD) genes in parallel from all subjects, incl…
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2024
2024
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