Rapid response to emerging biomedical challenges and threats

Grabowski, M.; Macnar, Joanna M.; Cymborowski, M.; Cooper, David R.; Minor, W.; Gilski, Mirosław; Brzeziński, Dariusz; Kowiel, Marcin; Dauter, Zbigniew; Rupp, Bernhard; Wlodawer, Alexander; Jaskólski, Mariusz; Minor, W.

doi:10.1107/s2052252521003018

IUCrJ

2021

DOI: 10.1107/s2052252521003018

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Rapid response to emerging biomedical challenges and threats

M. Grabowski

¹

,

Joanna M. Macnar

²

,

M. Cymborowski

³

et al.

Abstract: As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural data has given rise to multiple resources dedicated to assessing the correctness and quality of structural data and models. Here, an approach to evaluate the massive amounts of such data using the resource https://covi… Show more

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Cited by 8 publications

(9 citation statements)

References 58 publications

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“…Effective transformation of information and data into knowledge is challenging and requires a new way of viewing resources and databases. In our previous work, we presented recommendations 41 that should be coordinated on several levels involving different organizations. These suggestions could serve as a foundation for creating an Advanced Information System (AIS), 57,58 ensuring a rapid and efficient response plan for future pandemics.…”

Section: Resultsmentioning

confidence: 99%

“…These changes could improve the accuracy of data analysis. Additionally, in our previous paper, 41 we recommended actions that can be taken by different parties to unify and revamp the response to a crisis. We suggested implementing advanced information systems that can be used to improve communication and coordination among healthcare providers and public health officials, streamlining the response to a pandemic.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Structural biology and public health response to biomedical threats

Lenkiewicz

¹

,

Bijak

²

,

Poonuganti

³

et al. 2023

Structural Dynamics

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2

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Effective transformation of information and data into knowledge is challenging and requires a new way of viewing resources and databases. In our previous work, we presented recommendations 41 that should be coordinated on several levels involving different organizations. These suggestions could serve as a foundation for creating an Advanced Information System (AIS), 57,58 ensuring a rapid and efficient response plan for future pandemics.…”

Section: Resultsmentioning

confidence: 99%

“…These changes could improve the accuracy of data analysis. Additionally, in our previous paper, 41 we recommended actions that can be taken by different parties to unify and revamp the response to a crisis. We suggested implementing advanced information systems that can be used to improve communication and coordination among healthcare providers and public health officials, streamlining the response to a pandemic.…”

Section: Discussionmentioning

confidence: 99%

Structural biology and public health response to biomedical threats

Lenkiewicz

¹

,

Bijak

²

,

Poonuganti

³

et al. 2023

Structural Dynamics

Self Cite

2

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…It is also a commonly used tool in many biotechnology applications (Hess & Jewell, 2020; Table 2). Despite the relatively recent emergence of SARS-CoV-2 and its much smaller genome compared with T4 phage, structural biology studies of SARS-CoV-2 proteins are marching forward at an unprecedented pace (Grabowski et al, 2021) and hotspots from 16 distinct proteins have been characterized (Brzezinski et al, 2021). HIV-1 is another virus that has attracted long-standing interest and exhibits 23 protein clusters as defined by the 30% sequence-identity cutoff (Abram et al, 2010).…”

Section: Content Of the Virusmed Databasementioning

confidence: 99%

“…virusMED can serve as a blueprint for an Advanced Information System (AIS; pertaining to viruses, as it aims to provide novel analysis and gather information from more specialized databases and web resources. Collection of this information is essential to prepare for any future biomedical threats and challenges (Grabowski et al, 2021) by providing comprehensive and instantaneous avenues of research. The internal flexibility of virusMED allows the easy addition of features to increase the breadth of available data.…”

Section: Future Workmentioning

confidence: 99%

virusMED: an atlas of hotspots of viral proteins

Zhang

¹

,

Chen

²

,

Ma

³

et al. 2021

IUCrJ

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Almost immediately after publication of my 2020 editorial on the rapidity of the structural biology response to the COVID pandemic, I found substantial portions being quoted on Facebook and began receiving emails from family and friends from all around the world. Likewise, Wladek Minor, lead author on an article in the present issue of IUCrJ (Grabowski et al, 2021), tells me that he has never before received such immediate worldwide attention and interest. His article focused on protocols and tools to enable more effective responses to future biomedical threats.…”

mentioning

confidence: 99%

Some lessons from COVID: science and communication

Baker

¹

2021

IUCrJ

1

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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