Mitochondrial protein import stress

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Notably, in contrast to their paralogues, TIMM17A and DNAJC15 are unstable proteins 29,52 . Our results suggest that the proteolytic removal of this protein translocase as part of the OMA1-mediated stress response allows modulation to the mitochondrial import specificity to cope with unfavourable stress conditions 53 .…”

Section: Discussionmentioning

confidence: 83%

Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15

Kroczek¹,

Nolte²,

Lasarzewski³

et al. 2025

Preprint

1

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Core biological processes, including DNA replication, transcription, and translation, must occur within both mitochondria and the host cell, requiring the trafficking of the protein machinery involved in these processes to multiple, distinct cellular compartments. To ensure the proper localization of essential activities within mitochondria, most proteins are directed via a primary import pathway that relies on mitochondrial targeting signals present in the protein’s N-terminus of the protein 7 8 . These signals facilitate the translocation of unfolded proteins into the mitochondria through the TOM complex 7 .…”

Section: Introductionmentioning

confidence: 99%

Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease

Ly

¹

,

Tao

²

,

Bernardo

³

et al. 2025

Preprint

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Structural studies suggest CCDC127 as a novel membrane contact site protein in the mitochondrial intermembrane space

Bock-Bierbaum

¹

,

Malsburg

²

,

Natajan

³

et al. 2025

Preprint

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.