Structural studies suggest CCDC127 as a novel membrane contact site protein in the mitochondrial intermembrane space

Abstract: Mitochondria feature a sophisticated membrane architecture, with a planar mitochondrial outer membrane (MOM) and a folded inner membrane (MIM). Due to the remarkable adaptability of mitochondria, a proteinaceous network in the intermembrane space (IMS) was proposed to confer both stability and flexibility. However, components of such scaffolds, tentatively termed the 'mitoskeleton', have remained largely elusive. The mitochondrial contact site and organizing system (MICOS), a central organizer of mitochondrial… Show more