Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

Morgan, John T.; Chana, Gursharan; Pardo, Carlos A.; Achim, Cristian L.; Semendeferi, Katerina; Buckwalter, Jody; Courchesne, Eric; Everall, Ian

doi:10.1016/j.biopsych.2010.05.024

Biological Psychiatry

2010

DOI: 10.1016/j.biopsych.2010.05.024

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Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

John T. Morgan

¹

,

Gursharan Chana

²

,

Carlos A. Pardo

³

et al.

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Cited by 716 publications

(559 citation statements)

References 66 publications

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“…We next perform cell composition analysis to determine if any cell types are reduced or more abundant in the ASD cortex compared to controls (see Methods). In agreement with previous analysis (13,34,35), we detect a slight, but significant, increase in reactive forms of astrocytes and microglia. While previous analyses were limited in sample size and testing methods, our larger dataset affords a higher resolution: we specifically observe an increase in reactive astrocytes (ASTRO1), reactive microglia (MG2) and a trend for an increase in MG3, as well as OPCs (OPCS1 and OPCS3; Fig.…”

Section: Resultssupporting

confidence: 93%

Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics

Wamsley

¹

,

Bicks

²

,

Cheng

³

et al. 2023

Preprint

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…We next perform cell composition analysis to determine if any cell types are reduced or more abundant in the ASD cortex compared to controls (see Methods). In agreement with previous analysis (13,34,35), we detect a slight, but significant, increase in reactive forms of astrocytes and microglia. While previous analyses were limited in sample size and testing methods, our larger dataset affords a higher resolution: we specifically observe an increase in reactive astrocytes (ASTRO1), reactive microglia (MG2) and a trend for an increase in MG3, as well as OPCs (OPCS1 and OPCS3; Fig.…”

Section: Resultssupporting

confidence: 93%

Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics

Wamsley

¹

,

Bicks

²

,

Cheng

³

et al. 2023

Preprint

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…We next performed cell composition analysis to determine whether any cell types were reduced or more abundant in the ASD cortex compared with controls (see methods). In agreement with previous analysis ( 13 , 32 , 33 ), we detected a small but significant increase in reactive forms of microglia ( P = 0.04) and a similar trend in astrocytes ( P = 0.10) (Fig. 1F and table S2, A and B).…”

Section: Resultssupporting

confidence: 93%

Molecular cascades and cell type–specific signatures in ASD revealed by single-cell genomics

Wamsley

¹

,

Bicks

²

,

Cheng

³

et al. 2024

Science

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…In the present study, proin ammatory cytokine IL-1 β and oxidative stress marker HO-1 mRNAs were increased signi cantly in prefrontal cortex of male and female rats exposed to DE-SOA. Regarding brain immune cells, it has been reported that microglial activation was observed in brain especially in prefrontal cortex, cerebellum and cerebral white matter of patients with ASD [50,51]. These results are consistent with our present ndings showing activation of microglia in the prefrontal cortex of male rats exposed to DE-SOA.…”

Section: Discussionsupporting

confidence: 94%

Perinatal exposure to diesel exhaust origin secondary organic aerosol induces autism-like behavior in rats

Shwe

¹

,

Thu

²

,

Fujitani

³

et al. 2020

Preprint

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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