Dynamic reconfiguration of frontal brain networks during executive cognition in humans

Braun, Urs; Schäfer, Axel; Walter, Henrik; Erk, Susanne; Romanczuk‐Seiferth, Nina; Haddad, Leila; Schweiger, Janina I.; Grimm, O.; Heinz, Andreas; Tost, Heike; Meyer‐Lindenberg, Andreas; Bassett, Danielle S.

doi:10.1073/pnas.1422487112

Proc. Natl. Acad. Sci. U.S.A.

2015

DOI: 10.1073/pnas.1422487112

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Dynamic reconfiguration of frontal brain networks during executive cognition in humans

Urs Braun

¹

,

Axel Schäfer

²

,

Henrik Walter

³

et al.

Abstract: The brain is an inherently dynamic system, and executive cognition requires dynamically reconfiguring, highly evolving networks of brain regions that interact in complex and transient communication patterns. However, a precise characterization of these reconfiguration processes during cognitive function in humans remains elusive. Here, we use a series of techniques developed in the field of "dynamic network neuroscience" to investigate the dynamics of functional brain networks in 344 healthy subjects during a … Show more

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Cited by 849 publications

(925 citation statements)

References 64 publications

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73

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849

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“…This result may appear to be inconsistent with findings from a study by Yin and colleagues 13 who reported an association between resting state neural flexibility and cognitive performance, but there are key differences in study design which may account for these differing patterns of results That being said, other studies in adult samples have found relationships between task-based neural flexibility and cognitive outcomes 11,12 similar to those identified in the present study.…”

Section: Discussioncontrasting

confidence: 99%

The role of neural flexibility in cognitive aging

Varangis

¹

,

Qi

²

,

Stern

³

et al. 2021

Preprint

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…This result may appear to be inconsistent with findings from a study by Yin and colleagues 13 who reported an association between resting state neural flexibility and cognitive performance, but there are key differences in study design which may account for these differing patterns of results That being said, other studies in adult samples have found relationships between task-based neural flexibility and cognitive outcomes 11,12 similar to those identified in the present study.…”

Section: Discussioncontrasting

confidence: 99%

The role of neural flexibility in cognitive aging

Varangis

¹

,

Qi

²

,

Stern

³

et al. 2021

Preprint

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…15 ). These results are in line with growing literature on the importance of PFC-centered functional networks in spatiotemporal integration of information critical for flexible cognitive processes and successful goal-directed behavior 12 , 34 .…”

Section: Resultssupporting

confidence: 90%

Persistent neuronal activity in human prefrontal cortex links perception and action

Haller

¹

,

Case

²

,

Crone

³

et al. 2017

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Thus, the tendency for older adults with higher WM capacity to integrate more in the difficult task condition implies that this increase in integration is an adaptive benefit to WM. This pattern of correlations also suggests that in younger adults, the segregation of the task network from non-task regions is similarly adaptive, but in the reverse direction; such a pattern of greater segregation associated with positive outcomes for behavior is consistent with other studies finding a link between increase modularity and WM performance in younger populations ( Braun et al, 2015 ; Stanley et al, 2014 ).…”

Section: Resultssupporting

confidence: 88%

Older adults benefit from more widespread brain network integration during working memory

Crowell

¹

,

Davis

²

,

Beynel

³

et al. 2020

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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