Adaptation of human cell populations to different levels of centriole amplification

Abstract: Centrioles are the main components of cilia and centrosomes, which play a central role in cell proliferation and signalling. Their number is strictly regulated. Centriole amplification, or the presence of extra centrioles, often occurs in tumours and leads to aneuploidy and altered signalling and has been associated with cancer development and malignancy. Negative selection of cells with extra centrioles prevents numerical errors from expanding in the population, resulting in an overproduction-selection balanc… Show more