YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

Craig‐Schapiro, Rebecca; Perrin, Richard J.; Roe, Catherine M.; Xiong, Chengjie; Carter, Deborah; Cairns, Nigel J.; Mintun, Mark A.; Peskind, Elaine R.; Li, Ge; Galasko, Douglas; Clark, Christopher M.; Quinn, Joseph F.; D’Angelo, Gina; Malone, James P.; Townsend, R. Reid; Morris, John C.; Fagan, Anne M.; Holtzman, David M.

doi:10.1016/j.biopsych.2010.08.025

Biological Psychiatry

2010

DOI: 10.1016/j.biopsych.2010.08.025

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

Rebecca Craig‐Schapiro

¹

,

Richard J. Perrin

²

,

Catherine M. Roe

³

et al.

Abstract: Background Disease-modifying therapies for Alzheimer’s disease (AD) would be most beneficial if applied during the ‘preclinical’ stage (pathology present with cognition intact) before significant neuronal loss occurs. Therefore, biomarkers that can detect AD pathology in its early stages and predict dementia onset and progression will be invaluable for patient care and efficient clinical trial design. Methods 2D–difference gel electrophoresis and liquid chromatography tandem mass spectrometry were used to me… Show more

Help me understand this report

Cited by 494 publications

(567 citation statements)

References 50 publications

Supporting

45

Mentioning

512

Contrasting

9

Unclassified

1

Order By: Relevance

“…In contrast to previous studies of the CSF in aging 72,85 and AD, 76,77,79,82,86 our analyses reveal that the same biological processes change in both of these conditions but to a different extent. This suggests that CSF changes in AD reflect a perturbed process of physiological aging.…”

Section: Discussion and Study Conclusioncontrasting

confidence: 99%

Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus

Čarná

¹

,

Onyango

²

,

Katina

³

et al. 2023

Alzheimer's & Dementia

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…In contrast to previous studies of the CSF in aging 72,85 and AD, 76,77,79,82,86 our analyses reveal that the same biological processes change in both of these conditions but to a different extent. This suggests that CSF changes in AD reflect a perturbed process of physiological aging.…”

Section: Discussion and Study Conclusioncontrasting

confidence: 99%

Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus

Čarná

¹

,

Onyango

²

,

Katina

³

et al. 2023

Alzheimer's & Dementia

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Our finding of increased CSF YKL-40 levels in APOE ε4 carriers contrasts with previous literature [18] , [19] , [20] , including one article published with the same sample here studied [21] . Unlike these, we here sought for differences between carriers and noncarriers after accounting for demographic and diagnostic factors.…”

Section: Discussioncontrasting

confidence: 99%

The APOE ε4 genotype modulates CSF YKL‐40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2

Gispert

¹

,

Monté

²

,

Suárez‐Calvet

³

et al. 2016

Alz & Dem Diag Ass & Dis Mo

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Although this increase is more pronounced in Aβ‐positive than in negative individuals (as shown by the β slopes), the fact that there is no interaction between Aβ and age indicates that Aβ does not significantly modify the association between age and the specific CSF biomarker. These results are in line with previous studies that show that glial biomarkers increase with aging and also in other neurological diseases besides AD 27‐36 . Of note, our sample comprises a higher prevalence of A+T– than A+T+ individuals.…”

Section: Discussionsupporting

confidence: 93%

Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum

Milà‐Alomà

¹

,

Salvadó

²

,

Gispert

³

et al. 2020

Alzheimer's & Dementia

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA