XANTUS: a real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation

Camm, A. John; Amarenco, Pierre; Haas, Sylvia; Hess, Susanne; Kirchhof, Paulus; Kuhls, Silvia; Eickels, Martin van; Turpie, Alexander G.G.

doi:10.1093/eurheartj/ehv466

Eur Heart J

2015

DOI: 10.1093/eurheartj/ehv466

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XANTUS: a real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation

A. John Camm

¹

,

Pierre Amarenco

²

,

Sylvia Haas

³

et al.

Abstract: AimsAlthough non-vitamin K antagonist oral anticoagulants are recommended for stroke prevention in patients with non-valvular atrial fibrillation (NVAF) based on clinical trial results, there is a need for safety and efficacy data from unselected patients in everyday clinical practice. XANTUS investigated the safety and efficacy of the Factor Xa inhibitor rivaroxaban in routine clinical use in the NVAF setting.Methods and resultsConsecutive consenting patients with NVAF newly started on rivaroxaban were eligib… Show more

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Cited by 458 publications

(397 citation statements)

References 20 publications

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37

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294

Contrasting

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“…Additional side effects could have been realized during the longer follow-up period of our study, in comparison to large studies. A recent international, prospective and observational study of rivaroxaban showed a 20.1% discontinuation rate at 1 year which is slightly higher than our results 17 . In Norway, from 2013 to 2015, 20% of dabigatran users, 16% of warfarin users, 12% of rivaroxaban users, and 6% of apixaban users switched to another oral anticoagulant within 12 months of the first dispensing 11 .…”

Section: Discussioncontrasting

confidence: 92%

Reasons for discontinuation of novel oral anticoagulant therapy in patients with atrial fibrillation

Mitrović¹,

Folkeringa

²

,

Veeger

³

et al. 2020

Current Medical Research and Opinion

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Additional side effects could have been realized during the longer follow-up period of our study, in comparison to large studies. A recent international, prospective and observational study of rivaroxaban showed a 20.1% discontinuation rate at 1 year which is slightly higher than our results 17 . In Norway, from 2013 to 2015, 20% of dabigatran users, 16% of warfarin users, 12% of rivaroxaban users, and 6% of apixaban users switched to another oral anticoagulant within 12 months of the first dispensing 11 .…”

Section: Discussioncontrasting

confidence: 92%

Reasons for discontinuation of novel oral anticoagulant therapy in patients with atrial fibrillation

Mitrović¹,

Folkeringa

²

,

Veeger

³

et al. 2020

Current Medical Research and Opinion

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…[6][7][8] Moreover, lack of lowrisk patients in the ROCKET-AF raised a question regarding its effectiveness and safety in lower risk patients. Our study, consistent with a previous French study comparing rivaroxaban and warfarin 21 and observations from registries of rivaroxaban patients, 48,49 supports the effectiveness and safety of rivaroxaban in patients with various baseline risks of stroke and bleeding. The comparative effectiveness and safety of dabigatran versus warfarin appear to be somewhat attenuated in routine clinical practice.…”

Section: Discussionsupporting

confidence: 92%

Effectiveness and Safety of Dabigatran, Rivaroxaban, and Apixaban Versus Warfarin in Nonvalvular Atrial Fibrillation

Yao

¹

,

Abraham

²

,

Sangaralingham

³

et al. 2016

JAHA

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…The difference was especially remarkable in comparison with the ROCKET AF trial, where more than half of the population (54.9%) experienced previous stroke or TIA [5], while in the CRAFT study it was only 12.7%. The present results are not isolated, and they are in line with a recently performed prospective, observational Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation (XANTUS) study, where 19% of patients with non-valvular AF experienced previous stroke or TIA [16].…”

Section: Discussionsupporting

confidence: 91%

Randomized controlled clinical trials versus real-life atrial fibrillation patients treated with oral anticoagulants. Do we treat the same patients?

Balsam

¹

,

Tymińska

²

,

Ozierański

³

et al. 2013

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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