Biological Psychiatry
 2010
DOI: 10.1016/j.biopsych.2010.09.031
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Validating γ Oscillations and Delayed Auditory Responses as Translational Biomarkers of Autism

Michael J. Gandal
1
,
J. Christopher Edgar
2
,
Richard S. Ehrlichman
3
et al.

Abstract: Background Difficulty modeling complex behavioral phenotypes in rodents (e.g., language) has hindered pathophysiological investigation and treatment development for autism spectrum disorders (ASD). Recent human neuroimaging studies, however, have identified functional biomarkers that can be more directly related to the abnormal neural dynamics of ASD. This study assessed the translational potential of auditory evoked-response endophenotypes of autism in parallel mouse and human studies of autism. Methods Who… Show more

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Cited by 320 publications

(370 citation statements)
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References 64 publications

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“…In this study, auditory gamma‐band evoked power deficits in ASD failed to reach significance. While the differential significance (ITC significant, evoked power not significant) for the group differences in phase‐locked gamma‐band activity metrics is contrary to previous studies [Edgar et al, ; Rojas et al, ], non‐significant trends for reduced evoked power in ASD have also been reported previously [Gandal et al, ]. The lack of significance of the decrease in evoked power may be due to the use of a larger age range in the current study or other undetermined population effects.…”
Section: Discussioncontrasting
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…In this study, auditory gamma‐band evoked power deficits in ASD failed to reach significance. While the differential significance (ITC significant, evoked power not significant) for the group differences in phase‐locked gamma‐band activity metrics is contrary to previous studies [Edgar et al, ; Rojas et al, ], non‐significant trends for reduced evoked power in ASD have also been reported previously [Gandal et al, ]. The lack of significance of the decrease in evoked power may be due to the use of a larger age range in the current study or other undetermined population effects.…”
Section: Discussioncontrasting
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Significance was assessed with a group x drug x minute repeated measures ANOVA. Consistent with our previous findings, VPA-treated mice showed no difference in baseline LMA compared with SAL controls (F(1,43) = 0.24, P = 0.63) [15] . Likewise, there was no significant effect of MPEP on LMA (F(1,43) = 3.17, P = 0.09; Fig 3 ), nor was there a significant group by drug interaction (F(1,43) = 0.04, P = 0.84).…”
Section: Resultssupporting
confidence: 92%
“…To determine if the effect of MPEP was mediated simply by reducing anxiety-like behavior in the VPA group, we next assessed this behavioral domain with an open-field paradigm. Consistent with previous reports of increased anxiety-like behavior in this model [15] , [26] , VPA-exposed mice exhibited significantly fewer center entries than SAL-exposed mice (F(1,43) = 5.65, P = 0.02; Fig 2a ), although center time did not reach statistical significance between groups (F(1,43) = 2.85, P = 0.09; Fig 2b ). There was no effect of MPEP on the number of center entries (F(1,43) = 0.61, P = 0.44) or percentage of time spent in center (F(1,43) = 1.46, P = 0.23).…”
Section: Resultssupporting
confidence: 91%
“…Self-grooming activity has been widely employed as an index of repetitive behavior relevant to the core symptom domain in several other preclinical studies of autism [20] , [21] , [23] , [24] . A main effect of group (F(1,47) = 9.361, P<0.004) indicated that VPA-exposed mice groomed themselves significantly more than SAL-exposed mice over the 10-minute testing session, consistent with previous results ( Fig 1a ) [15] . In addition, treatment with MPEP significantly reduced self-grooming behavior across both groups (F(1,47) = 7.10, P = 0.011).…”
Section: Resultssupporting
confidence: 90%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…3C ). The data indicate that spectral power before the tone onset was much smaller, suggesting that the ITC increases before the tone onset (see below) were not ascribed to noisy EEG activities, consistent with the previous studies [ 43 , 44 , 45 , 46 ].…”
Section: Resultssupporting
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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