2020
DOI: 10.1101/2020.01.30.927871
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Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag

Prashant Pradhan
1
,
Ashutosh Pandey
2
,
Akhilesh Mishra
3
et al.

Abstract: We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019-nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV s… Show more

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Cited by 220 publications

(162 citation statements)
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“…Examining the genetic insight of SARS and Wuhan-Hu-1-CoV presented more than 90% sequence conservation between the E, M and N protein with few numbers of point mutations (Table 1), whereas the higher rate of mutations in the S protein of Wuhan-Hu-1-CoV were also observed and shared~81% identity (Table 1, Figure 4A). These results were in accordance with the results of Xu et al and Pradhan et al [44,45].…”
Section: Discussionsupporting
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Examining the genetic insight of SARS and Wuhan-Hu-1-CoV presented more than 90% sequence conservation between the E, M and N protein with few numbers of point mutations (Table 1), whereas the higher rate of mutations in the S protein of Wuhan-Hu-1-CoV were also observed and shared~81% identity (Table 1, Figure 4A). These results were in accordance with the results of Xu et al and Pradhan et al [44,45].…”
Section: Discussionsupporting
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…A group of Dutch scietists with Dr Van Doremalen [2] published their finding in March 13, 2020 in the New England Journal of Medicine, that HCOV-19 (which is also called SARS-COV2) is similar to SARS-COV1. That supports the earlier finding of a group of Indian scientists with the lead scientist, Prasant Pradhan, and 8 other scientists of School of Biology of the IIT Delhi, that the unique insertion in the 2019-nCOV of spike protein of HIV-1 gp 120 and HIV -1 Gag, which give this virus ability to destroy bodys natural immunity [3].…”
Section: Introductionsupporting
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…We also found 4 other non-contiguous HIV SIV regions summarized in [14][15][16][17][18][19][20] and [5].…”
Section: Evidence For 4 Others Hiv/siv Eie Sequences In Others Areas Of Covid-19 Genomementioning
confidence: 57%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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