Osteoarthritis and Cartilage
 2014
DOI: 10.1016/j.joca.2014.03.009
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Trajectories and risk profiles of pain in persons with radiographic, symptomatic knee osteoarthritis: data from the osteoarthritis initiative

John Collins
1
,
J.N. Katz
2
,
Elizabeth E. Dervan
3
et al.

Abstract: Background Little is known about the temporal evolution of pain severity in persons with knee OA. We sought to describe the pain trajectory over 6 years in a cohort of subjects with radiographic, symptomatic knee OA. Methods We used data from the Osteoarthritis Initiative (OAI), a multi-center, longitudinal study of subjects with diagnosed radiographic evidence of knee OA. Pain was assessed at baseline and annually for 6 years. Our analysis cohort included subjects with symptomatic knee OA at baseline, defin… Show more

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Cited by 241 publications

(239 citation statements)
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“…Our finding that pain progression follows several clusters, or trajectories, is consistent with previous findings; however, the number and shape of these trajectories are different 3,4 . These disparities may stem from the following differences in our approach.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Our finding that pain progression follows several clusters, or trajectories, is consistent with previous findings; however, the number and shape of these trajectories are different 3,4 . These disparities may stem from the following differences in our approach.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Our findings were consistent with those of Collins et al , who identified 5 WOMAC knee pain trajectories among the participants who had radiographic OA and WOMAC pain score >0 at baseline and were followed for 6 years. We included eligible participants regardless of their radiographic OA status at baseline and with WOMAC pain score ≥0 up to 8 years.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Interestingly, a subanalysis of our data revealed that 6/7 subjects who were scored as having severe meniscus extrusion were women. This fact aligns with recent observations that asymptomatic females exhibit relatively higher degrees of meniscus body extrusion than their male counterparts[20]. …”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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