Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

Maude, Shannon L.; Laetsch, Theodore W.; Buechner, Jochen; Rives, Susana; Boyer, Michael; Bittencourt, Henrique; Bader, Peter; Verneris, Michael R.; Stefanski, Heather E.; Myers, Gary D.; Qayed, Muna; Moerloose, Barbara De; Hiramatsu, Hidefumi; Schlis, Krysta; Davis, Kara L.; Martin, Paul L.; Nemecek, Eneida R.; Yanik, Gregory A.; Peters, Christina; Baruchel, André; Boissel, Nicolas; Méchinaud, Françoise; Balduzzi, Adriana; Krueger, Joerg; June, Carl H.; Levine, Bruce L.; Wood, Patricia A.; Taran, Tetiana; Leung, Mimi; Mueller, Karen T.; Zhang, Yiyun; Sen, Kapildeb; Lebwohl, David; Pulsipher, Michael A.; Grupp, Stephan A.

doi:10.1056/nejmoa1709866

N Engl J Med

2018

DOI: 10.1056/nejmoa1709866

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Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

Shannon L. Maude

¹

,

Theodore W. Laetsch

²

,

Jochen Buechner

³

et al.

Abstract: In this global study of CAR T-cell therapy, a single infusion of tisagenlecleucel provided durable remission with long-term persistence in pediatric and young adult patients with relapsed or refractory B-cell ALL, with transient high-grade toxic effects. (Funded by Novartis Pharmaceuticals; ClinicalTrials.gov number, NCT02435849 .).

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Cited by 5,290 publications

(4,844 citation statements)

References 24 publications

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“…23 Novel treatment options for B-cell ALL, including monoclonal antibodies and CAR T cells, may also have therapeutic potential in these patients. 24,25 However, our case does not confirm these observations. Considering patient´s refraction to given treatment, the chance for finding new possible drug sensitivities could lay in performing drug response profiling studies.…”

Section: Discussioncontrasting

confidence: 99%

Very rare near‐haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR‐T therapy in 19‐year‐old male patient

Jelínková¹,

Hrabovský

²

,

Oršulová

³

et al. 2022

Clinical Case Reports

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…23 Novel treatment options for B-cell ALL, including monoclonal antibodies and CAR T cells, may also have therapeutic potential in these patients. 24,25 However, our case does not confirm these observations. Considering patient´s refraction to given treatment, the chance for finding new possible drug sensitivities could lay in performing drug response profiling studies.…”

Section: Discussioncontrasting

confidence: 99%

Very rare near‐haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR‐T therapy in 19‐year‐old male patient

Jelínková¹,

Hrabovský

²

,

Oršulová

³

et al. 2022

Clinical Case Reports

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…The safety profile of tisagenlecleucel observed in this long-term follow-up analysis was consistent with published reports, 4,5 and no new AEs or treatment-related mortality were observed (Data Supplement). The proportion of patients with grade 3/4 AEs declined over time (83.5% of patients < 8 weeks after infusion, 49% from 8 weeks to 1 year, and 29% > 1 year).…”

Section: Resultssupporting

confidence: 91%

Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial

Laetsch

¹

,

Maude

²

,

Rives

³

et al. 2023

JCO

Self Cite

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Consistent with this, we demonstrate that primary NHL samples display a remarkable amount of heterogeneity in CD19 expression, which could account for the lower reported response rates in this disease compared with B-ALL (1,5,7,9,10,60). Using the well-described NALM6 preclinical model, we demonstrate the limited activity of CD19 CARs against low-antigen-density tumor cells, in line with previously reported data for various CARs (16)(17)(18)(19)(20)56).…”

Section: The Cd28 H/t Domain Results In Faster Tumor-cell Killing Andsupporting

confidence: 89%

Tuning the Antigen Density Requirement for CAR T-cell Activity

Majzner

¹

,

Rietberg²,

Sotillo³

et al. 2020

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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