2019
DOI: 10.1111/tmi.13233
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Timing of combination antiretroviral therapy (cART) initiation is not associated with stillbirth among HIV‐infected pregnant women in Malawi

Abstract: objective To assess the association between timing of maternal combination ART (cART) initiation and stillbirth among HIV-infected pregnant women in Malawi's Option B+ programme.methods Cohort study of HIV-infected pregnant women delivering singleton live or stillborn babies at ≥28 weeks of gestation using routine data from maternity registers between 1 January 2012 and 30 June 2015. We defined stillbirth as death of a foetus at ≥28 weeks of gestation. We report proportions of stillbirth according to timing of… Show more

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Cited by 12 publications

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“…While a meta-analysis in 2017 suggested preconception ART was associated with higher rates of adverse outcomes, this report included older studies using less optimal ART regimens. 38 Other studies using ART regimens recommended over the past 5 years such as the EFV-based ART regimen used in Lesotho have, similar to our study, not found timing of ART to be associated with adverse outcome 39 41 …”
Section: Discussionsupporting
confidence: 76%
“…While a metaanalysis in 2017 suggested preconception ART was associated with higher rates of adverse outcomes, this report included older studies using less optimal ART regimens. 38 Other studies using ART regimens recommended over the past 5 years such as the EFV-based ART regimen used in Lesotho have, similar to our study, not found timing of ART to be associated with adverse outcome [39][40][41] Our study had several strengths. We prospectively followed up women and collected primary data in a public healthcare setting that implemented the WHO guidelines for HIV treatment and PMTCT.…”
Section: Discussionsupporting
confidence: 58%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…While a meta-analysis in 2017 suggested preconception ART was associated with higher rates of adverse outcomes, this report included older studies using less optimal ART regimens. 38 Other studies using ART regimens recommended over the past 5 years such as the EFV-based ART regimen used in Lesotho have, similar to our study, not found timing of ART to be associated with adverse outcome 39 41 …”
Section: Discussionsupporting
confidence: 76%
“…While a metaanalysis in 2017 suggested preconception ART was associated with higher rates of adverse outcomes, this report included older studies using less optimal ART regimens. 38 Other studies using ART regimens recommended over the past 5 years such as the EFV-based ART regimen used in Lesotho have, similar to our study, not found timing of ART to be associated with adverse outcome [39][40][41] Our study had several strengths. We prospectively followed up women and collected primary data in a public healthcare setting that implemented the WHO guidelines for HIV treatment and PMTCT.…”
Section: Discussionsupporting
confidence: 58%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This collaboration combines data from HIV programs to study antiretroviral treatment, including pregnant individuals. The group has published studies from Brazil,[45,46] Malawi,[47] South Africa,[48] and the West African region. [49]…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This collaboration combines data from HIV programmes to study antiretroviral treatment, including pregnant individuals. The group has published studies from Brazil,45 46 Malawi,47 South Africa48 and the West African region 49…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.