2019 Timing of combination antiretroviral therapy (
Timing of combination antiretroviral therapy (cART ) initiation is not associated with stillbirth among HIV ‐infected pregnant women in Malawi
Abstract: objective To assess the association between timing of maternal combination ART (cART) initiation and stillbirth among HIV-infected pregnant women in Malawi's Option B+ programme.methods Cohort study of HIV-infected pregnant women delivering singleton live or stillborn babies at ≥28 weeks of gestation using routine data from maternity registers between 1 January 2012 and 30 June 2015. We defined stillbirth as death of a foetus at ≥28 weeks of gestation. We report proportions of stillbirth according to timing of…
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2025
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Cited by 12 publications
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References 38 publications
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“…While a meta-analysis in 2017 suggested preconception ART was associated with higher rates of adverse outcomes, this report included older studies using less optimal ART regimens. 38 Other studies using ART regimens recommended over the past 5 years such as the EFV-based ART regimen used in Lesotho have, similar to our study, not found timing of ART to be associated with adverse outcome 39 – 41 …”
Section: Discussionsupporting
confidence: 76%
“…While a meta-analysis in 2017 suggested preconception ART was associated with higher rates of adverse outcomes, this report included older studies using less optimal ART regimens. 38 Other studies using ART regimens recommended over the past 5 years such as the EFV-based ART regimen used in Lesotho have, similar to our study, not found timing of ART to be associated with adverse outcome 39 – 41 …”
Section: Discussionsupporting
confidence: 76%
“…While a metaanalysis in 2017 suggested preconception ART was associated with higher rates of adverse outcomes, this report included older studies using less optimal ART regimens. 38 Other studies using ART regimens recommended over the past 5 years such as the EFV-based ART regimen used in Lesotho have, similar to our study, not found timing of ART to be associated with adverse outcome [39][40][41] Our study had several strengths. We prospectively followed up women and collected primary data in a public healthcare setting that implemented the WHO guidelines for HIV treatment and PMTCT.…”
Section: Discussionsupporting
confidence: 58%
“…This collaboration combines data from HIV programs to study antiretroviral treatment, including pregnant individuals. The group has published studies from Brazil,[45,46] Malawi,[47] South Africa,[48] and the West African region. [49]…”
Section: Resultsmentioning
confidence: 99%
“…This collaboration combines data from HIV programmes to study antiretroviral treatment, including pregnant individuals. The group has published studies from Brazil,45 46 Malawi,47 South Africa48 and the West African region 49…”
Section: Resultsmentioning
confidence: 99%
