Expert Opinion on Drug Discovery
 2023
DOI: 10.1080/17460441.2023.2246881
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The current role and evolution of X-ray crystallography in drug discovery and development

Vanessa Bijak
1
,
Michal Szczygiel
2
,
Joanna Lenkiewicz
3
et al.
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Cited by 31 publications

(15 citation statements)
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“…For instance, studies on large ribonucleoprotein complexes used the high-resolution information garnered with X-ray crystallography for individual subunits in conjunction with lower resolution cryo-EM maps of the multimeric complex to generate composite models (Bai et al ., 2015). This synergy not only validates the individual findings of each method but also creates a more robust picture of the larger molecular architecture, which provides information that is essential for our understanding of biological mechanisms, and for the development of novel therapeutic interventions (Bijak et al ., 2023).…”
Section: The Expanding Toolkit Of Structural Biologymentioning
confidence: 61%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…For instance, studies on large ribonucleoprotein complexes used the high-resolution information garnered with X-ray crystallography for individual subunits in conjunction with lower resolution cryo-EM maps of the multimeric complex to generate composite models (Bai et al ., 2015). This synergy not only validates the individual findings of each method but also creates a more robust picture of the larger molecular architecture, which provides information that is essential for our understanding of biological mechanisms, and for the development of novel therapeutic interventions (Bijak et al ., 2023).…”
Section: The Expanding Toolkit Of Structural Biologymentioning
confidence: 61%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Although this study using multi-target screening rather than single-target screening helps reduce off-target effects, using more targets in molecular docking and protein microarray to screen anti-osteoarthritis compounds will be more useful. Additionally, protein microarray, immunoprecipitation, X-ray crystallography, and gene knockout models can be used to evaluate the interaction between compounds and proteins [ 47 – 50 ].…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Although the study preliminarily explored the binding mechanism between aptamers and AZA-2 using computer simulations, the research exploring the mechanism is not yet in-depth. In the future, multiple technical means, such as X-ray crystallography and nuclear magnetic resonance, should be further employed to deeply analyze the interaction mechanism between aptamers and their targets [ 55 , 56 ].…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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