The connectome of the adult Drosophila mushroom body provides insights into function

Li, Feng; Lindsey, Jack; Marin, Elizabeth C.; Otto, Nils; Dreher, Marisa; Dempsey, Georgia; Stark, Ildiko; Bates, Alexander Shakeel; Pleijzier, Markus William; Schlegel, Philipp; Nern, Aljoscha; Takemura, Shin-ya; Eckstein, Nils; Yang, Tansy; Francis, Audrey; Braun, Amalia; Parekh, Ruchi; Costa, Marta; Scheffer, Louis K.; Aso, Yoshinori; Jefferis, Gregory S.X.E.; Abbott, Larry; Litwin-Kumar, Ashok; Waddell, Scott; Rubin, Gerald M.

doi:10.7554/elife.62576

Elife

2020

DOI: 10.7554/elife.62576

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The connectome of the adult Drosophila mushroom body provides insights into function

Feng Li

¹

,

Jack Lindsey

²

,

Elizabeth C. Marin

³

et al.

Abstract: Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome, and extensive prior experimental studies of its roles in learning, memory and activity regulation. Here we identify new components of the MB circuit in Drosophila, including extensive visual inpu… Show more

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Cited by 417 publications

(762 citation statements)

References 222 publications

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27

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729

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“…Another prominent input to the KCγ-d population is the large inhibitory neuron APL, which makes on average 16 and 10 synapses per KCγ-d in the left and right hemispheres respectively (comparable to the average number of synapses APL makes onto each KCγ-m). In contrast to a previous observation that KCγ-d’s do not have clawed dendrites 7 , we observe KCγ-d’s that make bouton-claw and en passant synapses with incoming VPNs and LVINs (Supplementary Fig. 1A-C ).…”

Section: Resultscontrasting

confidence: 99%

Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body

Ganguly

¹

,

Heckman

²

,

Litwin-Kumar

³

et al. 2024

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Another prominent input to the KCγ-d population is the large inhibitory neuron APL, which makes on average 16 and 10 synapses per KCγ-d in the left and right hemispheres respectively (comparable to the average number of synapses APL makes onto each KCγ-m). In contrast to a previous observation that KCγ-d’s do not have clawed dendrites 7 , we observe KCγ-d’s that make bouton-claw and en passant synapses with incoming VPNs and LVINs (Supplementary Fig. 1A-C ).…”

Section: Resultscontrasting

confidence: 99%

Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body

Ganguly

¹

,

Heckman

²

,

Litwin-Kumar

³

et al. 2024

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Another prominent input to the KCγ-d population is the large inhibitory neuron APL, which makes on average 16 and 10 synapses per KCγ-d in the left and right hemispheres respectively (comparable to the average number of synapses APL makes onto each KCγ-m). In contrast to a previous observation that KCγ-d’s do not have clawed dendrites 7 , we observe KCγ-d’s that make bouton-claw and en passant synapses with incoming VPNs and LVINs (Figure 1 Supplement 1).…”

Section: Resultscontrasting

confidence: 99%

Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body

Ganguly

¹

,

Heckman

²

,

Litwin-Kumar

³

et al. 2023

Preprint

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Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…To investigate this, we focused on tracing pathways between the MB – the fly’s main learning and memory center – and the CX ( Figures 46 and 47 ). In agreement with results from a companion manuscript focusing on the MB ( Li et al, 2020 ) and trans-Tango-based circuit mapping ( Scaplen et al, 2021 ), we found extensive pathways leading from MBONs to FB tangential neurons. In the context of navigation, the MB is considered a potential source of visual snapshot memory, which may allow insects to base their navigation decisions on remembered panoramic views ( Collett and Collett, 2018 ; Sun et al, 2020 ).…”

Section: Discussionsupporting

confidence: 91%

“…We began by examining the projection patterns of all core CX neuron types that contact neurons in other brain regions ( Figure 54A ). These neurons target a narrow column around the CX that extends through the BU, GA, CRE, LAL, SPS, WED, RUB, ROB, SMP, SLP, IPS, and SPS ( Figure 54A and B ), as partially described in previous studies ( Hanesch et al, 1989 ; Li et al, 2020 ; Lin et al, 2013 ; Rayshubskiy et al, 2020 ; Wolff et al, 2015 ; Wolff and Rubin, 2018 ). The neural projections and synapse locations within these regions appear to largely segregate by type (see Figure 54B ).…”

Section: Resultssupporting

confidence: 74%

A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

Hulse

¹

,

Haberkern

²

,

Franconville

³

et al. 2021

Elife

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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