Journal of Controlled Release
 2010
DOI: 10.1016/j.jconrel.2010.08.004
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies

Amnon Sintov
1
,
Haim V. Levy2,
Shafir Botner
3
Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
80
15
3
2

Citation Types

1
44
0
0

Year Published

2011
2011
2025
2025

Publication Types

Select...
86
6
3
1

Relationship

3
93

Authors

Journals

citations

Cited by 96 publications

(45 citation statements)
references

References 44 publications

1
44
0
0
Order By: Relevance
“…Interesting result obtained from monitoring blood glucose level after intranasal administration showed similar glucose lowering ability for both test formulations and standard subcutaneously administered insulin. This is similar to previously reported results by Sintov et al [18] and Forst et al [19]. This shows that this formulation can release therapeutically sufficient quantities of insulin to achieve normoglycemia.…”
Section: Time (H)supporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Interesting result obtained from monitoring blood glucose level after intranasal administration showed similar glucose lowering ability for both test formulations and standard subcutaneously administered insulin. This is similar to previously reported results by Sintov et al [18] and Forst et al [19]. This shows that this formulation can release therapeutically sufficient quantities of insulin to achieve normoglycemia.…”
Section: Time (H)supporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The average droplet size of drugunloaded microemulsion containing 20% water (surfactants-to-oil ratio = 87:13) was 2 nm in diameter (99.7% of total droplets). Our previous studies using this microemulsion system showed that loading of drug molecules and even of protein drugs into the nano-droplets did not much change the average droplet size [25].…”
Section: Resultsmentioning
confidence: 83%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…This approach enables controlled drug release, faster absorption, and a less invasive alternative that enhances patient adherence. Intranasal delivery also offers additional advantages, such as reduced discomfort compared to subcutaneous injections and the potential to bypass hepatic metabolism, favoring a more rapid and direct effect on glycemic control [ 87 , 88 , 89 , 90 , 91 ]. Therefore, intranasal insulin nano- and microemulsions represent a significant advancement in diabetes therapy by combining efficacy, convenience, and improved patient comfort.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo