Front. Immunol.
 2022
DOI: 10.3389/fimmu.2022.777733
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection

Maya Gough
1
,
Dhiraj Kumar Singh
2
,
Bindu Singh
3
et al.

Abstract: Mycobacterium tuberculosis (Mtb) has developed specialized mechanisms to parasitize its host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst and persist in the wake of an inflammatory response. Mtb infection in the majority of those exposed is controlled in an asymptomatic form referred to as latent tuberculosis infection (LTBI). HIV is a well-known catalyst of reactivation of LTBI to active TB infection (ATB). Through the use of nonhuman primates (NHPs) co-infected with … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1
1
0

Citation Types

0
5
0
0

Year Published

2023
2023
2025
2025

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations

Cited by 6 publications

(5 citation statements)
references

References 76 publications

0
5
0
0
Order By: Relevance
“…For example, several genes were found to be up-regulated within the host cells, playing a major role during the infection such as SECTM1, LYPD4 and HSPA6 . SECTM1 is a protein involved in immune processes [20, 21]. In addition, HSPA6, a poorly known protein serving as a positive regulator in Enterovirus-A71, was also found to be induced [22].…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…For example, several genes were found to be up-regulated within the host cells, playing a major role during the infection such as SECTM1, LYPD4 and HSPA6 . SECTM1 is a protein involved in immune processes [20, 21]. In addition, HSPA6, a poorly known protein serving as a positive regulator in Enterovirus-A71, was also found to be induced [22].…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Alongside genetic tools, toxin-induced models are employed to study CNS disorders [ 53 ]. NHPs also remain irreplaceable in infectious disease research ( Table 4 ), enabling the investigation of single- and multi-pathogen interactions [ 54 ].…”
Section: Large-animal Modelmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Therefore, differential expression levels of ADM may mediate the distinct functions of macrophages, leading to different outcomes after Mtb infection. Another study, utilizing transcriptome analysis of a Mtb ‐infected monkey model, revealed significant differences in functional genes of macrophages between LTBI and ATB, such as type I interferon (IFN‐I) pathway genes (Gough et al, 2022). Peripheral blood IFN‐I signaling pathways have been reported to significantly differ between LTBI and ATB patients and serve as crucial indicators for distinguishing the two conditions (Singhania et al, 2018; Zhang et al, 2021).…”
Section: Immuno‐cytological Characteristics Of Ltbi and Atbmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo