iScience
 2022
DOI: 10.1016/j.isci.2022.104449
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Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env

Edgar A. Hodge
1
,
Gajendra S. Naika
2
,
Sally Kephart
3
et al.
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Cited by 22 publications

(33 citation statements)
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“…However, subclassification in the accompanying report 39 revealed that about one-third of the BG505 HT1 trimers bound to one CD4 adopted an open trimer conformation that superimposed well onto our cryo-ET structure of Env bound to one CD4 molecule 39 . The results from both laboratories are therefore consistent, particularly as it is known that a more CD4-resistant tier 2 HIV-1 isolate such as BG505 is less responsive to CD4 than the tier 1b isolate HIV-1 BaL used for cryo-ET 10 , 38 . The similar structures determined by cryo-ET and cryo-EM SPA demonstrate the existence of asymmetric intermediates of Env during CD4 receptor binding.…”
Section: Discussionsupporting
confidence: 62%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…However, subclassification in the accompanying report 39 revealed that about one-third of the BG505 HT1 trimers bound to one CD4 adopted an open trimer conformation that superimposed well onto our cryo-ET structure of Env bound to one CD4 molecule 39 . The results from both laboratories are therefore consistent, particularly as it is known that a more CD4-resistant tier 2 HIV-1 isolate such as BG505 is less responsive to CD4 than the tier 1b isolate HIV-1 BaL used for cryo-ET 10 , 38 . The similar structures determined by cryo-ET and cryo-EM SPA demonstrate the existence of asymmetric intermediates of Env during CD4 receptor binding.…”
Section: Discussionsupporting
confidence: 62%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…In contrast to other structurally analyzed Env trimers, the CZA97.012 trimer has a fully resolved V4 loop, which suggests a relatively stable antigenic surface there, probably because the shortness of this loop, a characteristic of Clade C isolates [121]. This greater stability might favor certain broad but claderestricted NAb responses [122][123][124][125]. Whether this stability and exposure are conducive to eliciting intra-Clade breadth or merely promote off-target narrow responses cannot de determined by our data.…”
Section: Plos Pathogensmentioning
confidence: 61%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…1). Here, we propose two scenarios that could lead to the production of this type of antibody: This hypothesis is supported by studies of the dynamics of Env trimers showing structural changes occurring in the absence of CD4 that suggest that trimers can be in equilibrium between closed and more open conformations (65). Support for this model comes from biological studies.…”
Section: Discussionmentioning
confidence: 73%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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