Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity

Ge, Ming‐Xia; Jiang, Jianjun; Yang, Liqin; Yang, Xing‐Li; He, Yonghan; Li, Gong‐Hua; Kong, Qing‐Peng

doi:10.3390/genes13050749

Genes

2022

DOI: 10.3390/genes13050749

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Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity

Ming‐Xia Ge

¹

,

Jianjun Jiang

²

,

Liqin Yang

³

et al.

Abstract: Deep RNA sequencing of 164 blood samples collected from long-lived families was performed to investigate the expression patterns of circular RNAs (circRNAs). Unlike that observed in previous studies, circRNA expression in long-lived elderly individuals (98.3 ± 3.4 year) did not exhibit an age-accumulating pattern. Based on weighted circRNA co-expression network analysis, we found that longevous elders specifically gained eight but lost seven conserved circRNA-circRNA co-expression modules (c-CCMs) compared wit… Show more

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Cited by 5 publications

(3 citation statements)

References 47 publications

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“…It has been proposed that the functioning of a living organism heavily depends on the functional coordination of its genes and that the loss of this coordination leads to the onset and progression of pathological states ( Ge et al, 2022 ). Additionally, it is known that aging leads to a loss of functional organization and gene modularity ( Southworth et al, 2009a ).…”

Section: Discussionmentioning

confidence: 99%

Gene co-expression networks reveal sex-biased differences in musculoskeletal ageing

Olascoaga

¹

,

Tovar

²

,

Espinal‐Enríquez

³

2024

Front. Aging

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…It has been proposed that the functioning of a living organism heavily depends on the functional coordination of its genes and that the loss of this coordination leads to the onset and progression of pathological states ( Ge et al, 2022 ). Additionally, it is known that aging leads to a loss of functional organization and gene modularity ( Southworth et al, 2009a ).…”

Section: Discussionmentioning

confidence: 99%

Gene co-expression networks reveal sex-biased differences in musculoskeletal ageing

Olascoaga

¹

,

Tovar

²

,

Espinal‐Enríquez

³

2024

Front. Aging

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…On the other hand, RNA-seq has been widely used to affiliate the expression patterns of protein coding gene (PCG), long noncoding RNA (lncRNA) and circular RNA (circRNA). Increasing evidence has shown that lncRNAs and circRNAs are closely related with degenerative diseases ( Bhatti et al., 2021 ), cancers ( Anastasiadou et al., 2018 ) development ( Fatica and Bozzoni, 2014 ; Di Agostino et al., 2020 ), aging ( Jiang et al., 2021 ; Ge et al., 2022 ), and they have great potential to be utilized as drug targets in the near future ( Matsui and Corey, 2017 ; He et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Insights into the mechanisms of triptolide nephrotoxicity through network pharmacology-based analysis and RNA-seq

Luo

¹

,

Yang

²

,

Wen

³

et al. 2023

Self Cite

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Their circular structure endows them with high stability which, along with their presence in different bio uids and their involvement in different physiological and pathological processes (Kristensen et al, 2019), has attracted the interest of many researchers as a promising source of biomarkers. Importantly, among the different physiological and pathological processes, circRNAs have been linked to aging (Haque et al, 2020), longevity (Ge et al, 2022), and age-associated phenotypes such as immunosenescence (Y. H. Wang, Yu, Luo, & Han, 2015) and mitochondrial dysfunction (Song et al, 2020). Nevertheless, to our knowledge, so far, circRNAs have not been studied in relation to frailty.…”

Section: Introductionmentioning

confidence: 99%

Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals

Iparraguirre

¹

,

Alberro

²

,

Iñiguez

³

et al. 2022

Preprint

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Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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