Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

Disanto, Giulio; Barro, Christian; Benkert, Pascal; Naegelin, Yvonne; Schädelin, Sabine; Giardiello, Antonella; Zecca, Chiara; Blennow, Kaj; Zetterberg, Henrik; Leppert, David; Kappos, Ludwig; Gobbi, Claudio; Kühle, Jens

doi:10.1002/ana.24954

Annals of Neurology

2017

DOI: 10.1002/ana.24954

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

Giulio Disanto

¹

,

Christian Barro

²

,

Pascal Benkert

³

et al.

Abstract: ObjectiveNeurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single‐molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).MethodssNfL levels were measured in healthy controls (HC, n = 254) and two independent MS cohorts: (1) cross‐sectional with pair… Show more

Help me understand this report

Cited by 1,093 publications

(1,375 citation statements)

References 53 publications

Supporting

93

Mentioning

1,242

Contrasting

15

Unclassified

22

Order By: Relevance

“…Our analysis demonstrated that serum levels of the investigated molecular biomarkers did not predict the progression of physical disability defined by any of the three different EDSS-based criteria (see the Methods section). These results remain in contrast with several previous studies showing correlation between serum NfL levels and disability progression in PMS patients [ 7 , 63 ]. Also, CSF levels of NfL and/or YKL-40 were suggested as predictors of neurological disability accumulation in progressive MS patients [ 27 , 62 ].…”

Section: Discussioncontrasting

confidence: 99%

No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients

Gajewski

¹

,

Karlińska

²

,

Domowicz

³

et al. 2025

Biomolecules

2

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Our analysis demonstrated that serum levels of the investigated molecular biomarkers did not predict the progression of physical disability defined by any of the three different EDSS-based criteria (see the Methods section). These results remain in contrast with several previous studies showing correlation between serum NfL levels and disability progression in PMS patients [ 7 , 63 ]. Also, CSF levels of NfL and/or YKL-40 were suggested as predictors of neurological disability accumulation in progressive MS patients [ 27 , 62 ].…”

Section: Discussioncontrasting

confidence: 99%

No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients

Gajewski

¹

,

Karlińska

²

,

Domowicz

³

et al. 2025

Biomolecules

2

0

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…These measures did not show a significant correlation (Spearman correlation (r s ) = −0.107, p = n.s. ), in line with findings by others 4,10 . We therefore did not consider this variable in further analysis.…”

Section: Resultssupporting

confidence: 94%

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Khalil

¹

,

Pirpamer

²

,

Hofer

³

et al. 2020

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…12,20,21 Our cross-sectional analyses confirm previous reports stating that sNfL concentrations are associated with clinical disability and cognitive performance, the number of T2 lesions, T2 lesion volume and the presence of new T2 lesions. 2,5,22,23 However, we found no significant associations between sNfL and normalized brain volume measures, in contrast to what was observed by Barro et al 8 One explanation for this could be that our patient population had lower disability scores at baseline and were treated with more highly effective DMTs. In addition, the follow-up time was relatively short.…”

Section: Discussioncontrasting

confidence: 95%

Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis

Brune

¹

,

Høgestøl

²

,

Benavent

³

et al. 2022

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA