EMBO Mol Med
 2016
DOI: 10.15252/emmm.201506123
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sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

Marc Suárez‐Calvet
1
,
Gernot Kleinberger
2
,
Miguel Ángel Araque Caballero
3
et al.

Abstract: TREM2 is an innate immune receptor expressed on the surface of microglia. Loss‐of‐function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD). TREM2 is a type‐1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (sTREM2), which can be measured in the cerebrospinal fluid (CSF). In this cross‐sectional multicenter study, we investigated whether CSF levels of sTREM2 are changed during the clinical course of AD, a… Show more

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Cited by 504 publications

(586 citation statements)
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“…Regarding the sTREM2 trajectory, in contrast to the results of Suárez-Calvet et al, our study did not observe a faster increase in sTREM2 levels among individuals with MCI or dementia compared to cognitively normal individuals [ 42 ]. This divergence in findings might be attributed to the different age ranges of the study samples (40–100 years vs. 54–94 years).…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Regarding the sTREM2 trajectory, in contrast to the results of Suárez-Calvet et al, our study did not observe a faster increase in sTREM2 levels among individuals with MCI or dementia compared to cognitively normal individuals [ 42 ]. This divergence in findings might be attributed to the different age ranges of the study samples (40–100 years vs. 54–94 years).…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…As seems to be the case for many other conditions, including cerebral small vessel disease [37], NFL in CAA is likely to find utility as a marker of the intensity of neurodegeneration and so a useful measure of prognosis rather than diagnosis, particularly as it can be measured in the serum; further work is needed to investigate this. We did not find any differences in sTREM2 between the AD, CAA, or control groups; this is in contrast with previous studies, in which sTREM2 was found to be elevated in the CSF of AD patients [38][39][40][41][42]. Again, our inability to identify a statistically significant difference might result from our relatively small sample size.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…This result is supported by another report where a positive correlation between CSF Aβ42 and CSF sTREM2 was described (30). However, it differs from other reports that describe a significant positive correlation between CSF sTREM2 and CSF t-tau and p-tau, but no correlation with CSF Aβ42 (26, 28, 37). The reason for the differences between our study and these previous studies is unknown but may include cohort differences in frequency of APOE ε4 or other factors.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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