Journal of Alzheimer’s Disease
 2013
DOI: 10.3233/jad-131409
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Risk Factors for Development of Dementia in a Unique Six-Year Cohort Study. I. An Exploratory, Pilot Study of Involvement of the E4 Allele of Apolipoprotein E, Mutations of the Hemochromatosis-HFE Gene, Type 2 Diabetes, and Stroke

Maire E. Percy
1
,
Martin J. Somerville
2
,
Mark Hicks
3
et al.

Abstract: Risk factors for dementia development are not well-defined. We evaluated several factors alone and in combination in a unique cohort of Caucasian volunteers over an approximately 6-year observation window using a nested case/control design. Factors included: apolipoprotein E (ApoE) gene variants (the E4 allele is the strongest confirmed genetic predisposing factor for Alzheimer's disease), the hemochromatosis-HFE gene mutations (H63D and C282Y), diabetes, and stroke. At study entry, subjects were ≥65 years of … Show more

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Cited by 30 publications

(28 citation statements)
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“…We did not replicate the previous finding of an effect of HFE SNPs on risk of AD and an epistatic interaction for risk with APOE ε4 genotype, but we cannot yet rule out an association of HFE SNPs with AD age of onset or phenotypic interactions [25,27,28].…”
Section: Discussioncontrasting
confidence: 99%
“…Our results suggest that there is not a causal connection between lifetime peripheral iron measures and increased risk of AD. We did not replicate the previous finding of an effect of HFE SNPs on risk of AD and an epistatic interaction for risk with APOE ε4 genotype, but we cannot yet rule out an association of HFE SNPs with AD age of onset or phenotypic interactions [25,27,28].…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…We did not replicate the previous finding of an effect of HFE SNPs on risk of AD and an epistatic interaction for risk with APOE ε4 genotype, but we cannot yet rule out an association of HFE SNPs with AD age of onset or phenotypic interactions [25,27,28].…”
Section: Discussioncontrasting
confidence: 99%
“…Our results suggest that there is not a causal connection between lifetime peripheral iron measures and increased risk of AD. We did not replicate the previous finding of an effect of HFE SNPs on risk of AD and an epistatic interaction for risk with APOE ε4 genotype, but we cannot yet rule out an association of HFE SNPs with AD age of onset or phenotypic interactions [25,27,28].…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…In contrast, HFE genotype was the best differentiating factor between AtAD cases and controls; the same variant was also the first genetic risk factor for broad AD in individuals without APOE ε4. These findings are consistent with prior research implicating HFE in AD risk in individuals without APOE ε4 [ 60 ]. These results also suggest that atypical presentations could represent a distinct genetic class of AD, although the present study was not designed to specifically address this question.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The findings of a strongly increased dementia mortality risk for ε4 carriers and of a protective effect for ε2 carriers were similar to other reports, in which dementia was clinically diagnosed [4,5,11]. For example, in the Rotterdam study, the ε4ε4 genotype was associated with an eleven-fold risk of dementia compared to the ε3ε3 type [5] (we found a seven-fold OR).…”
Section: Discussionsupporting
confidence: 79%
“…Furthermore, the study reported an OR of 0.5 for the ε2ε3 type and an OR of 1.7 for the ε3ε4 type compared to the ε3ε3 type [5] (we found an OR of 0.6 for the ε2ε3 type and of 2.0 for the ε3ε4 type compared to the ε3ε3 type). Almost identical results as ours were reported in the Finnish CAIDE study, where the ε4 carriers had an OR of 2.3 for developing dementia [4], and in a Canadian nested case-control study, ε4 carriers had an OR of 2.5 for developing dementia according to the DSM-IV-TR criteria [11] (we found an OR of 2.5). …”
Section: Discussionsupporting
confidence: 77%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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