RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children

“…Therefore, a functional deficiency of either vitamin results in elevated concentrations of homocysteine. Our results are consistent with several observations in autistic children: increased frequency of methylenetetrahydrofolate reductase (MTHFR) allele variants (Boris et al, 2004) favoring the increase in plasma Hcy (Frosst et al, 1995); elevation of cerebrospinal fluid (CSF) tHcy and clinical improvement after folinic acid administration (Moretti et al, 2005), reduced ileal absorption of B 12 in conjunction with a reported intestinal pathology (Wakefield et al, 1998;White, 2003); reported low levels of IGF-1 in CSF (Vanhala et al, 2001), which in turn is capable of decreasing methionine synthase activity (Waly et al, 2004). These observations suggest that hyperhomocysteinemia, previously associated with several neuropsychiatric disorders (Sachdev, 2004), might also be present in autism.…”