RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

Valastyan, Scott; Reinhardt, Ferenc; Benaich, Nathan; Calogrias, Diana; Szász, Attila Marcell; Wang, Zhigang C.; Brock, Jane E.; Richardson, Andrea L.; Weinberg, Robert A.

doi:10.1016/j.cell.2009.03.047

Cell

2009

DOI: 10.1016/j.cell.2009.03.047

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RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

Scott Valastyan

¹

,

Ferenc Reinhardt²,

Nathan Benaich

³

et al.

Abstract: SUMMARY MicroRNAs are well-suited to regulate tumor metastasis due to their capacity to coordinately repress numerous target genes, thereby potentially enabling their intervention at multiple steps of the invasion-metastasis cascade. We identify a microRNA exemplifying these attributes, miR-31, whose expression correlates inversely with metastasis in human breast cancer patients. Overexpression of miR-31 in otherwise-aggressive breast tumor cells suppresses metastasis. We deploy a stable microRNA sponge strate… Show more

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Cited by 785 publications

(736 citation statements)

References 41 publications

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32

Mentioning

691

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5

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“…On the other hand, our data differ from those reported by Valastyan et al [56], Creighton et al [57], and Ivanov and colleagues [58], who have observed that miR-31 functions as a tumor suppressor in breast and ovarian carcinomas, as well as malignant pleural mesotheliomas. Discrepancies regarding our findings and those of the latter investigators may be attributable in part to genetic and epigenetic profiles of the various malignancies, reprogramming [59], tissue-specific effects of basal and inducible miR-31 expression, and Wnt signaling [60], [61].…”

Section: Discussioncontrasting

confidence: 99%

“…Our findings, as well as those of Liu et al [47] are consistent with data demonstrating that up-regulation of miR-31 in oropharyngeal and colorectal carcinomas correlates with advanced stage of disease, and decreased survival of patients with these malignancies [45] , [48] . On the other hand, our data differ from those reported by Valastyan et al [56] , Creighton et al [57] , and Ivanov and colleagues [58] , who have observed that miR-31 functions as a tumor suppressor in breast and ovarian carcinomas, as well as malignant pleural mesotheliomas. Discrepancies regarding our findings and those of the latter investigators may be attributable in part to genetic and epigenetic profiles of the various malignancies, reprogramming [59] , tissue-specific effects of basal and inducible miR-31 expression, and Wnt signaling [60] , [61] .…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Cigarette Smoke Induces C/EBP-β-Mediated Activation of miR-31 in Normal Human Respiratory Epithelia and Lung Cancer Cells

Xi

¹

,

Yang

²

,

Tao

³

et al. 2010

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…On the other hand, our data differ from those reported by Valastyan et al [56], Creighton et al [57], and Ivanov and colleagues [58], who have observed that miR-31 functions as a tumor suppressor in breast and ovarian carcinomas, as well as malignant pleural mesotheliomas. Discrepancies regarding our findings and those of the latter investigators may be attributable in part to genetic and epigenetic profiles of the various malignancies, reprogramming [59], tissue-specific effects of basal and inducible miR-31 expression, and Wnt signaling [60], [61].…”

Section: Discussioncontrasting

confidence: 99%

“…Our findings, as well as those of Liu et al [47] are consistent with data demonstrating that up-regulation of miR-31 in oropharyngeal and colorectal carcinomas correlates with advanced stage of disease, and decreased survival of patients with these malignancies [45] , [48] . On the other hand, our data differ from those reported by Valastyan et al [56] , Creighton et al [57] , and Ivanov and colleagues [58] , who have observed that miR-31 functions as a tumor suppressor in breast and ovarian carcinomas, as well as malignant pleural mesotheliomas. Discrepancies regarding our findings and those of the latter investigators may be attributable in part to genetic and epigenetic profiles of the various malignancies, reprogramming [59] , tissue-specific effects of basal and inducible miR-31 expression, and Wnt signaling [60] , [61] .…”

Section: Discussioncontrasting

confidence: 99%

Cigarette Smoke Induces C/EBP-β-Mediated Activation of miR-31 in Normal Human Respiratory Epithelia and Lung Cancer Cells

Xi

¹

,

Yang

²

,

Tao

³

et al. 2010

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…In order to do so, we orthotopically implanted into the mammary fat pads of mice 231 cells expressing either shRNAs against the mRNAs encoding these three factors or, alternatively, a miR-31 expression vector. Consistent with our prior findings (6, 7), miR-31 enhanced primary mammary tumor growth by 1.5-fold; in contrast, the combined shRNA-evoked suppression of ITGA5, RDX, and RhoA failed to affect primary tumor size (Fig. 2A).…”

Section: Resultssupporting

confidence: 92%

Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis

Valastyan

¹

,

Chang

²

,

Benaich

³

et al. 2010

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Among these, miR-9, miR-31, miR-34 family and miR-224 have been previously reported to be deregulated in human cancers (29-32). Interestingly, we found that miR-31was up-regulated in N1+ patients in our study cohort (Figure 1A) consistent with miR-31 previously reported to be up-regulated in metastatic colon cancer (33) but contrary to the reported high expression of miR-31 associated with reduced frequency of metastases in breast cancer (34). …”

Section: Resultssupporting

confidence: 91%

MicroRNA-31 Predicts the Presence of Lymph Node Metastases and Survival in Patients with Lung Adenocarcinoma

Meng

¹

,

Ye

²

,

Cui

³

et al. 2013

Clinical Cancer Research

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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