Elife
 2017
DOI: 10.7554/elife.17584
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Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

Christine Mantis
1
,
Irawati Kandela
2
,
Fraser Aird
3

Abstract: In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015) that described how we intended to replicate selected experiments from the paper “Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs“ (Sugahara et al., 2010). Here we report the results of those experiments. We found that coadministration with iRGD peptide did not have an impact on permeability of the chemotherapeutic agent doxorubicin (DOX) in a xenograft m… Show more

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Cited by 54 publications

(33 citation statements)
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“…Then the signal gradually decreased, and only very weak fluorescence signal could be detected in kidneys six h after the injection (Figure 1C,F,I). This result indicated the delivery of small molecules to tumors was not significantly improved by the coadministration with PAD peptosomes or iRGD peptides, which is consistent with the replication study by Mantis et al but conflicts with the others [22,23,35,36,37]. Differences in the cell line, the injected reagents, and the coadministration procedures between our work and others can contribute to the inconsistency of the outcome.…”
Section: Resultssupporting
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Then the signal gradually decreased, and only very weak fluorescence signal could be detected in kidneys six h after the injection (Figure 1C,F,I). This result indicated the delivery of small molecules to tumors was not significantly improved by the coadministration with PAD peptosomes or iRGD peptides, which is consistent with the replication study by Mantis et al but conflicts with the others [22,23,35,36,37]. Differences in the cell line, the injected reagents, and the coadministration procedures between our work and others can contribute to the inconsistency of the outcome.…”
Section: Resultssupporting
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…TUNEL staining was an indicator of cellular apoptosis, which can point out the cleaved DNA in the nucleus. [45] As shown in Fig. 5c, we observed a small number of cells with nuclei stained in the control group.…”
Section: Therapy Efficacy Of Hbo-assistant Chemotherapy In A549 Xenogsupporting
confidence: 52%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…None of the 5 reproducibility studies in our survey successfully replicated the original studies using either significance or effect-size criteria [ 17 – 21 ]. Thus, accurate forecasting would require a strongly pessimistic response pattern.…”
Section: Resultsmentioning
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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