Relationship Between Depression and Neurodegeneration: Risk Factor, Prodrome, Consequence, or Something Else? A Scoping Review

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Moreover, the point is that these landscapes are likely to be patient-specific. Genetics, microbial ecology, their lifestyle, and age will ultimately matter and determine their compositions in these basins; thus, classrooms of collapse may be remarkably different patient-to-patient [ 220 ]. For example, two patients with similar risk may behave completely differently; one stays in a stable basin, and the other progresses to disease.…”

Section: Integrative Systems Models and Control-theory Framework For ...mentioning

confidence: 99%

The Endocannabinoid–Microbiota–Neuroimmune Super-System: A Unifying Feedback Architecture for Systems Resilience, Collapse Trajectories, and Precision Feedback Medicine

Aliuş

¹

,

Breazu

²

,

Panţu

³

et al. 2025

IJMS

2

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Anxiety and cognitive disturbances often precede or coexist with depression [ 4 , 5 ]. Moreover, depression is commonly observed in the early stages of neurodegenerative diseases [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Psychobiotics in Depression: Sources, Metabolites, and Treatment—A Systematic Review

Śliwka

¹

,

Polak‐Berecka

²

,

Zdybel

³

et al. 2025

Nutrients

2

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Leptin a potential link between obesity and depression

Hontecilla-Prieto

¹

,

García-Domínguez

²

,

Berlanga-Gil

³

et al. 2025

Cell. Mol. Life Sci.

1

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.