Aliment Pharmacol Ther
 2016
DOI: 10.1111/apt.13790
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Real‐world effectiveness and safety of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin in hepatitis C: AMBER study

Robert Flisiak1,
Ewa Janczewska2,
Marta Wawrzynowicz‐Syczewska3
et al.

Abstract: Summary Background Virologic and safety outcomes of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin (OBV/PTV/r ± DSV ± RBV) therapy have shown high sustained virologic response (SVR) rates and good tolerability in most patient populations in pre‐registration studies. Aim To confirm these clinical trial findings in the treatment of genotype 1 and 4 hepatitis C under real‐world conditions. Methods Patients enrolled for treatment with OBV/PTV/r ± DSV ± RBV based on therapeutic guidelines were included, … Show more

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Cited by 104 publications

(125 citation statements)
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“…The presented real-life data showed very high efficacy (100% ETR and 98.9% SVR12) of the new DAAs (OBV/PTV/RTV + DSV + RBV) in patients with chronic HCV infection. This is in full accordance with results of other studies [9][10][11][12][13] .…”
Section: Discussionsupporting
confidence: 93%
“…This is in full accordance with European 9,10,14 and US real-world data 15 where predominant type was also genotype 1, while in RVR data suggest very rapid onset of action of DAAs with null viraemia in 91.66% of available patients. This result is in line with the Polish study were RVR was achieved in 69.23% 10 . ETR and SVR data showed 100% direct antiviral effectiveness of the used therapeutic regimen which was partly due to the well preserved hepatic function.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The presented real-life data showed very high efficacy (100% ETR and 98.9% SVR12) of the new DAAs (OBV/PTV/RTV + DSV + RBV) in patients with chronic HCV infection. This is in full accordance with results of other studies [9][10][11][12][13] .…”
Section: Discussionsupporting
confidence: 93%
“…This is in full accordance with European 9,10,14 and US real-world data 15 where predominant type was also genotype 1, while in RVR data suggest very rapid onset of action of DAAs with null viraemia in 91.66% of available patients. This result is in line with the Polish study were RVR was achieved in 69.23% 10 . ETR and SVR data showed 100% direct antiviral effectiveness of the used therapeutic regimen which was partly due to the well preserved hepatic function.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Regarding the safety profile of OBV/PTV/r + DSV therapy, the majority of adverse events were mild, and strongly associated with use of RBV. Pruritus, nausea, headache, and asthenia were the most common adverse events, in agreement with the results of previous clinical trials and real‐life studies . In our study, hyperbilirubinemia and anemia were also present in patients with RBV co‐administration but no ALT elevation was reported.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Our study is in accordance with previous real-life studies investigating the efficacy of OBV/PTV/r+DSV±RBV in chronic hepatitis C patients [9][10][11][12][17][18][19] with SVR rates between 86% and 100%. In real-life cohorts, patients who failed to achieve SVR were mainly cirrhotics [9][10][17][18]. In the study of Fox et al [17], SVR rates were lower for patients <65years, with cirrhosis, HCC, or a GT-non-1 infection.…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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