2024
DOI: 10.1101/2024.08.26.609777
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Proteome asymmetry in mouse and human embryos before fate specification

Lisa K. Iwamoto-Stohl
1
,
Aleksandra A. Petelski
2
,
Maciej Meglicki
3
et al.

Abstract: Pre-patterning of the embryo, driven by spatially localized factors, is a common feature across several non-mammalian species1–4. However, mammals display regulative development and thus it was thought that blastomeres of the embryo do not show such pre-patterning, contributing randomly to the three lineages of the blastocyst: the epiblast, primitive endoderm and trophectoderm that will generate the new organism, the yolk sac and placenta respectively4–6. Unexpectedly, early blastomeres of mouse and human embr… Show more

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“… 33 , 34 Neither protein abundance nor metabolome abundance can be directly inferred from mRNA levels. 35 , 36 For example, sc proteomic studies have identified developmental fates and cellular states that are not captured by sc RNA-seq 37 and have also revealed many proteins that are not predicted by the genetic code. 38 Orthogonal approaches can complement 27 − 32 and validate each other and access mechanistic details beyond linear regulatory programs.…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“… 33 , 34 Neither protein abundance nor metabolome abundance can be directly inferred from mRNA levels. 35 , 36 For example, sc proteomic studies have identified developmental fates and cellular states that are not captured by sc RNA-seq 37 and have also revealed many proteins that are not predicted by the genetic code. 38 Orthogonal approaches can complement 27 − 32 and validate each other and access mechanistic details beyond linear regulatory programs.…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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