Presence of SARS-CoV-2-reactive T cells in COVID-19 patients and healthy donors

Braun, Julian; Loyal, Lucie; Frentsch, Marco; Wendisch, Daniel; Georg, Philipp; Kurth, Florian; Hippenstiel, Stefan; Dingeldey, Manuela; Kruse, Beate; Fauchère, Florent; Baysal, Emre; Mangold, Maike; Henze, Larissa; Lauster, Roland; Mall, Marcus; Beyer, Kirsten; Röhmel, Jobst; Schmitz, Jürgen; Miltenyi, Stefan; Demuth, Ilja; Müller, Marcel A.; Witzenrath, Martin; Suttorp, Norbert; Kern, Florian; Reimer, Ulf; Wenschuh, Holger; Drosten, Christian; Corman, Victor M.; Giesecke‐Thiel, Claudia; Sander, Leif Erik; Thiel, Andreas

doi:10.1101/2020.04.17.20061440

2020

DOI: 10.1101/2020.04.17.20061440

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Presence of SARS-CoV-2-reactive T cells in COVID-19 patients and healthy donors

Julian Braun

¹

,

Lucie Loyal

²

,

Marco Frentsch

³

et al.

Abstract: 42 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a rapidly 43 unfolding pandemic, overwhelming health care systems worldwide 1 . Clinical manifestations of 44 Coronavirus-disease 2019 (COVID-19) vary broadly, ranging from asymptomatic infection to 45 acute respiratory failure and death 2 , yet the underlying mechanisms for this high variability are 46 still unknown. Similarly, the role of host immune responses in viral clearance of COVID-19 47 remains unresolved. For SARS-CoV (2002/03… Show more

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Cited by 226 publications

(289 citation statements)

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“…If we consider samples with a SI > 3 as responders, we identified 2 out of 10 HC (20%) to have these cross-reactive T-cells. This is in good accordance with a recent report on the presence of virus-specific CD4 + T-cells in COVID-19 patients, which reported the presence of SARS-CoV-2-reactive T-cells in 34% of the HC (Braun et al, 2020). The role of pre-existing SARS-CoV-2-reactive T-cells as a correlate of protection or pathology is unclear, and needs to be addressed in prospective studies.…”

Section: Resultssupporting

confidence: 93%

Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

Weiskopf

¹

,

Schmitz

²

,

Raadsen

³

et al. 2020

Preprint

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…If we consider samples with a SI > 3 as responders, we identified 2 out of 10 HC (20%) to have these cross-reactive T-cells. This is in good accordance with a recent report on the presence of virus-specific CD4 + T-cells in COVID-19 patients, which reported the presence of SARS-CoV-2-reactive T-cells in 34% of the HC (Braun et al, 2020). The role of pre-existing SARS-CoV-2-reactive T-cells as a correlate of protection or pathology is unclear, and needs to be addressed in prospective studies.…”

Section: Resultssupporting

confidence: 93%

Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

Weiskopf

¹

,

Schmitz

²

,

Raadsen

³

et al. 2020

Preprint

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Indeed cross-reactive TCRs predicted to target epitopes not unique to SARS-CoV-2 start at a higher level, and only seem to gradually increase as the infection progresses. This may be in line with prior reports of existing cross-reactive T cells in uninfected patients (9, 11, 32).…”

Section: Resultssupporting

confidence: 92%

Leveraging T-cell receptor – epitope recognition models to disentangle unique and cross-reactive T-cell response to SARS-CoV-2 during COVID-19 progression/resolution

Postovskaya

¹

,

Vujkovic

²

,

Block

³

et al. 2020

Preprint

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…4A,B). When taken in aggregate, our results are largely consistent with previous ORF-level analyses using peptide pools (7, 8, 15-17) . However, our approach provided an increased level of granularity that enabled us to identify specific epitope sequences and highlighted allele-specific differences.…”

Section: Resultssupporting

confidence: 90%

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2

Ferretti

¹

,

Kula

²

,

Wang

³

et al. 2020

Preprint

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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