J Exp Clin Cancer Res
 2024
DOI: 10.1186/s13046-024-03011-0
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Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice

Jie Dong
1
,
Lingkai Kong
2
,
Shiqun Wang
3
et al.

Abstract: Background Dysregulation of cholesterol metabolism is associated with the metastasis of triple-negative breast cancer (TNBC). Apolipoprotein A1 (ApoA1) is widely recognized for its pivotal role in regulating cholesterol efflux and maintaining cellular cholesterol homeostasis. However, further exploration is needed to determine whether it inhibits TNBC metastasis by affecting cholesterol metabolism. Additionally, it is necessary to investigate whether ApoA1-based oncolytic virus therapy can be u… Show more

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Cited by 7 publications

(5 citation statements)
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“…Taken together, these results position baculoviruses as robust antitumor gene therapy vectors that are important additions to the biomedical toolbox. In particular, we observed effects on tumor growth similar to other viral vectors currently in clinical trials, such as therapies based on both replicating and non-replicating adenoviruses [ 71 , 72 , 73 , 74 ].…”
Section: Discussionmentioning
confidence: 53%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Taken together, these results position baculoviruses as robust antitumor gene therapy vectors that are important additions to the biomedical toolbox. In particular, we observed effects on tumor growth similar to other viral vectors currently in clinical trials, such as therapies based on both replicating and non-replicating adenoviruses [ 71 , 72 , 73 , 74 ].…”
Section: Discussionmentioning
confidence: 53%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Overexpressing (ATF3-oe) and ATF3-knockdown (ATF3-kd) HCC cell lines. This panel encompassed genes encoding key enzymes involved in fatty acid synthesis (FASN, ACLY, and SCD) [ 28 ], components of lipoproteins (APOA1, APOB, and APOC3) [ 29 , 30 , 31 ], and regulators of lipid synthesis (mTORC1 and SREBF2) [ 32 , 33 ]. In ATF3-oe Huh7 cell lines, a significant decrease in the expression levels of all examined genes except mTORC1 was observed ( Figure 3 A).…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…Subsequently, they assessed the efficacy of ADV-ApoA1 in inhibiting TNBC growth and metastasis in several mouse models, including orthotopic breast cancer, spontaneous breast cancer, and human breast cancer xenografts. Additionally, comprehensive safety evaluations of ADV-ApoA1 were conducted in Syrian hamsters and rhesus monkeys 48 .…”
Section: Oncolytic Virus In Breast Cancermentioning
confidence: 99%
“…Moreover, Wei et al developed an oncolytic adenovirus encoding apolipoprotein A1 (AdV-ApoA1), which corrects aberrant cholesterol metabolism, reduces intracellular cholesterol levels, and leads to dephosphorylation of the transcription factor FOXO3, enabling its translocation into the nucleus. FOXO3 suppresses the transcription of the KRT14 gene by directly binding to its promoter region, thereby inhibiting the invasion and metastasis of TNBC cells 48 .…”
Section: Adenovirusmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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