Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Our findings appear to contrast with the results of the pivotal CheckMate 214 trial ( 8 ). Several factors may help explain this difference.…”

Section: Discussioncontrasting

confidence: 99%

Effectiveness and safety of nivolumab and ipilimumab in older adults with renal cell carcinoma: findings from a multicenter observational study in Poland

Drobniak

¹

,

Stokłosa

²

,

Grela-Wojewoda³

et al. 2025

Front. Oncol.

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Consistent with previous reports, 3 8 similar overall rates of treatment-related AEs of any grade occurred in the NIVO+IPI and SUN arms with extended follow-up (514/547 (94.0%) vs 521/535 (97.4%) patients). Yet, there were fewer grade 3–4 treatment-related AEs with NIVO+IPI versus SUN (47.3% vs 64.1%; online supplementary table S3 ).…”

Section: Resultssupporting

confidence: 90%

Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial

Motzer

¹

,

Escudier

²

,

McDermott

³

et al. 2020

J Immunother Cancer

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…The predictive relevance of PD-L1 expression on IC is further supported by the strong correlation of PD-L1 IC as determined by IHC with the T eff immune gene signature. These findings are consistent with results from other recently reported studies in mRCC 38,39 . Specifically, in a phase 3 study evaluating ipilimumab + nivolumab versus sunitinib, improved clinical benefit was observed in patients expressing PD-L1 on tumor cells (24% of enrolled patients) 39 .…”

Section: Discussionsupporting

confidence: 94%

“…These findings are consistent with results from other recently reported studies in mRCC 38,39 . Specifically, in a phase 3 study evaluating ipilimumab + nivolumab versus sunitinib, improved clinical benefit was observed in patients expressing PD-L1 on tumor cells (24% of enrolled patients) 39 . These data support development of PD-L1 IHC and/or an immune gene expression signature based diagnostic or enrichment strategy in treatment-naive patients with mRCC.…”

Section: Discussionsupporting

confidence: 94%

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

McDermott

¹

,

Huseni²,

Atkins

³

et al. 2018

Nat Med

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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