New insulin glargine 300 U/ml compared with glargine 100 U/ml in insulin‐naïve people with type 2 diabetes on oral glucose‐lowering drugs: a randomized controlled trial (EDITION 3)

Bolli, Geremia B.; Riddle, Matthew C.; Bergenstal, Richard M.; Ziemen, M.; Šeštakauskas, Kąstytis; Goyeau, Harmonie; Home, Philip

doi:10.1111/dom.12438

Diabetes Obesity Metabolism

2015

DOI: 10.1111/dom.12438

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

New insulin glargine 300 U/ml compared with glargine 100 U/ml in insulin‐naïve people with type 2 diabetes on oral glucose‐lowering drugs: a randomized controlled trial (EDITION 3)

Geremia B. Bolli

¹

,

Matthew C. Riddle

²

,

Richard M. Bergenstal

³

et al.

Abstract: AimsTo compare the efficacy and safety of new insulin glargine 300 U/ml (Gla-300) with that of glargine 100 U/ml (Gla-100) in insulin-naïve people with type 2 diabetes using oral glucose-lowering drugs.MethodsThe EDITION 3 study was a multicentre, open-label, parallel-group study. Participants were randomized to Gla-300 or Gla-100 once daily for 6 months, discontinuing sulphonylureas and glinides, with a dose titration aimed at achieving pre-breakfast plasma glucose concentrations of 4.4–5.6 mmol/l (80–100 mg/… Show more

Help me understand this report

Cited by 298 publications

(579 citation statements)

References 26 publications

Supporting

44

Mentioning

511

Contrasting

12

Unclassified

12

Order By: Relevance

“…As expected, Gla-300 was associated with lower rates of hypoglycemia compared with NPH insulin. Our findings are consistent with previous results in the EDITION trials in T2D patients where Gla-300 consistently reduced nocturnal hypoglycemia compared with Gla-100 with no differences in HbA1c [ 2 , 3 ]. With comparable HbA1c and FPG achieved between treatment groups, there were notable differences in GV and TIR between the Gla-300 and NPH groups that varied by time of day.…”

Section: Discussionsupporting

confidence: 92%

Glycemic Variability and Time in Range During Self-titration of Once Daily Insulin Glargine 300 U/ml Versus Neutral Protamine Hagedorn Insulin in Insulin-naïve Chinese Type 2 Diabetes Patients

Ling

¹

,

Poon

²

,

Yang

³

et al. 2021

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…As expected, Gla-300 was associated with lower rates of hypoglycemia compared with NPH insulin. Our findings are consistent with previous results in the EDITION trials in T2D patients where Gla-300 consistently reduced nocturnal hypoglycemia compared with Gla-100 with no differences in HbA1c [ 2 , 3 ]. With comparable HbA1c and FPG achieved between treatment groups, there were notable differences in GV and TIR between the Gla-300 and NPH groups that varied by time of day.…”

Section: Discussionsupporting

confidence: 92%

Glycemic Variability and Time in Range During Self-titration of Once Daily Insulin Glargine 300 U/ml Versus Neutral Protamine Hagedorn Insulin in Insulin-naïve Chinese Type 2 Diabetes Patients

Ling

¹

,

Poon

²

,

Yang

³

et al. 2021

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…FPG reductions observed at month 6 in the LATAM participants (LS mean change À50.58 mg/dl) were lower than those in the global ATOS 23 Overall, the incidence rates of documented symptomatic and severe hypoglycaemia (at night and at any time of the day) were low in ATOS LATAM. This finding is consistent with the aforementioned real-world studies, 20,23,26 RCTs 15,19 and the CONCLUDE trial. 31 It is important to note that none of the participants showed clinically relevant documented hypoglycaemia (blood glucose < 54 mg/dl [<3.0 mmol/L]), despite moderate reductions in HbA1c, FPG and fasting SMBG.…”

Section: Discussionsupporting

confidence: 92%

Real‐world effectiveness and safety of insulin glargine 300 U/ml in insulin‐naïve people with type 2 diabetes in the Latin America region: A subgroup analysis of the ATOS

Vargas‐Uricoechea

¹

,

Núñez²,

Guzmán³

et al. 2022

Diabetes Obesity Metabolism

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Studies in several Western populations with type 2 diabetes in the EDITION programme (EDITION 1, 2 and 3) have shown no difference in glycaemic control but less hypoglycaemia with Gla-300 than Gla-100 [10][11][12]. The results from the present study are consistent with previous EDITION studies and extend these findings to Japanese people with type 2 diabetes.…”

Section: Discussionsupporting

confidence: 91%

New insulin glargine 300 U/ml versus glargine 100 U/ml in Japanese people with type 2 diabetes using basal insulin and oral antihyperglycaemic drugs: glucose control and hypoglycaemia in a randomized controlled trial ( EDITION JP 2)

Terauchi

¹

,

Koyama

²

,

Cheng

³

et al. 2016

Diabetes Obesity Metabolism

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA