Mitochondria are required for pro‐ageing features of the senescent phenotype

Correia‐Melo, Clara; Marques, Francisco Madeira; Anderson, Rhys; Hewitt, Graeme; Hewitt, Rachael N.; Cole, John; Carroll, Bernadette; Miwa, Satomi; Birch, Jodie; Merz, Alina; Rushton, Michael D.; Charles, Michelle; Jurk, Diana; Tait, Stephen W. G.; Czapiewski, Rafal; Greaves, Laura C.; Nelson, Glyn; Bohlooly‐Y, Mohammad; Rodríguez‐Cuenca, Sergio; Vidal‐Puig, Antonio; Mann, Derek A.; Saretzki, Gabriele; Quarato, Giovanni; Green, Douglas R.; Adams, Peter D.; Zglinicki, Thomas von; Korolchuk, Viktor I.; Passos, João F.

doi:10.15252/embj.201592862

The EMBO Journal

2016

DOI: 10.15252/embj.201592862

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Mitochondria are required for pro‐ageing features of the senescent phenotype

Clara Correia‐Melo

¹

,

Francisco Madeira Marques

²

,

Rhys Anderson

³

et al.

Abstract: Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both functions are dependent on the development of the senescent phenotype, which involves an overproduction of pro‐inflammatory and pro‐oxidant signals. However, the exact mechanisms regulating these phenotypes remain poorly understood. Here, we show the critical role of mitochondria in cellular senescence. In multiple models of senescence, absence of mitochondria reduced a spectrum of senescence effectors and phenotypes while p… Show more

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Cited by 734 publications

(742 citation statements)

References 67 publications

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709

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“…The dysregulation of mitochondrial biogenesis, fusion, fission and mitophagy all contribute to changes in the mitochondrial pool in ageing and disease . Increased mitochondrial mass is reported in AECII and lung fibroblasts in IPF and airway smooth muscle (ASM) cells in severe asthma . In this study, increased levels of mtDNA and MitoTracker Green staining suggest IPF‐LFs also exhibit a net increase in mitochondrial mass as compared to Ctrl‐LFs, possibly a consequence of increased biogenesis.…”

Section: Discussioncontrasting

confidence: 99%

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

Schuliga

¹

,

Pechkovsky

²

,

Read

³

et al. 2018

J Cellular Molecular Medi

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…The dysregulation of mitochondrial biogenesis, fusion, fission and mitophagy all contribute to changes in the mitochondrial pool in ageing and disease . Increased mitochondrial mass is reported in AECII and lung fibroblasts in IPF and airway smooth muscle (ASM) cells in severe asthma . In this study, increased levels of mtDNA and MitoTracker Green staining suggest IPF‐LFs also exhibit a net increase in mitochondrial mass as compared to Ctrl‐LFs, possibly a consequence of increased biogenesis.…”

Section: Discussioncontrasting

confidence: 99%

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

Schuliga

¹

,

Pechkovsky

²

,

Read

³

et al. 2018

J Cellular Molecular Medi

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…2d). These data are in agreement with previous reports showing that senescent cells have a marked increase in mitochondrial activity 6,28,29 . To assess whether this increase in OCR during senescence was due to FASN activity, we used increasing concentrations of C75.…”

Section: Resultssupporting

confidence: 94%

FASN activity is important for the initial stages of the induction of senescence

Fafián‐Labora

¹

,

Carpintero-Fernández

²

,

Jordan

³

et al. 2019

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

“…Aged cells tend to have larger mitochondrial mass, which is consistent with our experimental results, 42 where the mitochondrial mass of MSCs on soft polyacrylamide gel was greater than that on the hard substrate (Figure 6A, B ). Furthermore, the aged environment is characterized by a high level of ROS, and during the osteogenic differentiation of MSCs, oxidative phosphorylation is the primary mode of energy metabolism, leading to a substantial production of ROS.…”

Section: Resultssupporting

confidence: 91%

Matrix stiffness regulates mitochondria‐lysosome contacts to modulate the mitochondrial network, alleviate the senescence of MSCs

Wang

¹

,

Ho

²

,

Li

³

et al. 2024

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

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