Front. Immunol.
 2025
DOI: 10.3389/fimmu.2025.1528770
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Manganese deficiency or dietary manganese(III) oxide nanoparticle supplementation: consequences for hematology, and intestinal and brain immunity in rats

Karolina Różaniecka-Zwolińska
1
,
Ewelina Cholewińska
2
,
Bartosz Fotschki
3
et al.

Abstract: IntroductionThe study aimed to determine the effect of manganese (Mn) exclusion from the mineral mixture added to the rat diet and replacing the recommended level of MnCO3 (65 mg Mn/kg diet) with Mn2O3 nanoparticles (Mn2O3NPs) in the diet on blood hematology and selected immunological indices of the blood, jejunum, and brain.MethodsThe experiment was conducted on twenty-four, Wistar rats divided into 3 equal groups. The control (K) group received a diet containing 65 mg/kg of additional Mn originating from the… Show more

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“…Manganese (Mn) is an essential trace element required for normal CNS function, playing key roles as a cofactor in several enzymes involved in antioxidant defense, neurotransmitter synthesis, and energy metabolism [ 35 ]. Notably, manganese is vital for the activity of mitochondrial SOD (Mn-SOD), arginase, and glutamine synthetase, which are critical for mitigating oxidative stress and supporting neuronal metabolism [ 61 ]. However, manganese exhibits a narrow therapeutic window, and excessive accumulation in the brain, particularly within the basal ganglia, can lead to neurotoxicity.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Manganese (Mn) is an essential trace element required for normal CNS function, playing key roles as a cofactor in several enzymes involved in antioxidant defense, neurotransmitter synthesis, and energy metabolism [ 35 ]. Notably, manganese is vital for the activity of mitochondrial SOD (Mn-SOD), arginase, and glutamine synthetase, which are critical for mitigating oxidative stress and supporting neuronal metabolism [ 61 ]. However, manganese exhibits a narrow therapeutic window, and excessive accumulation in the brain, particularly within the basal ganglia, can lead to neurotoxicity.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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“…The experimental design, methodological framework, and experimental procedures presented in this research article have previously been published by Sołek et al [ 26 ] and Różaniecka-Zwolińska et al [ 27 ]. The present experiment is part of a larger project to evaluate the effects of manganese deficiency and supplementation with manganese(III) oxide nanoparticles on the organism’s multi-aspect biological response.…”
Section: Methodsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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