Parkinsonism & Related Disorders
 2017
DOI: 10.1016/j.parkreldis.2017.09.018
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Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry

Angelo Antonini
1
,
Werner Poewe
2
,
К. Ray Chaudhuri
3
et al.
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Cited by 205 publications

(286 citation statements)
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“…In a real-life observational study, PD patients treated with CSAI, LCIG infusion, or bilateral subthalamic DBS, respectively, had improved PDQ-8, UPDRS-IV, and NMSS scores at 6 months 13 . By contrast to our findings, improvements in HRQoL over 36 months were found after DBS 41 or over 24 months after LCIG infusion 42 , 43 . Patients included in these studies might have significantly differed from patients in our study, due to the application of more stringent eligibility criteria.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…In a real-life observational study, PD patients treated with CSAI, LCIG infusion, or bilateral subthalamic DBS, respectively, had improved PDQ-8, UPDRS-IV, and NMSS scores at 6 months 13 . By contrast to our findings, improvements in HRQoL over 36 months were found after DBS 41 or over 24 months after LCIG infusion 42 , 43 . Patients included in these studies might have significantly differed from patients in our study, due to the application of more stringent eligibility criteria.…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…The beneficial effects of STN‐DBS on urinary symptoms and sexual function have previously been described. Furthermore, our results are consistent with previous studies that reported an improvement of the miscellaneous NMSS domain for STN‐DBS, IJLI, and APO . The present work confirms previous STN‐DBS studies that observed an improvement of pain, olfactory symptoms, and excessive sweating .…”
Section: Discussionsupporting
confidence: 93%
“…However, there are also conflicting results from studies that have reported a worsening of attention under APO treatment, and further studies are needed to investigate this issue. In addition, the present study confirms the observation of a significant improvement of gastrointestinal symptoms under IJLI therapy, which was reported by Antonini and colleagues in the GLORIA study. The beneficial effects of STN‐DBS on urinary symptoms and sexual function have previously been described.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
“…Further, dyskinesia was rarely reported as an ADR in the registry. These data are consistent with those reported in previous studies showing that continuous levodopa delivery reduces pre-existing dyskinesia, in addition to improving motor fluctuations [2], even though switching from oral PD medications to LCIG is usually associated with an increase in daily levodopa equivalent dose [2].…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
show abstract
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